Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae)
Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae)
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DOI：
10.1016/j.phytochem.2008.10.005
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发表时间：
2009-01-01
期刊：
影响因子：
3.8
通讯作者：
Litaudon, Marc
中科院分区：
文献类型：
--
作者：
Marti, Guillaume;Eparvier, Veronique;Litaudon, Marc
为了寻找抗疟药物，我们对法属圭亚那收集的 60 种植物提取物进行了对恶性疟原虫氯喹耐药菌株 (FcB1) 的系统体外评估。从红花莫罗诺贝亚乳胶中获得的甲醇提取物表现出很强的抗疟原虫活性（10 μg/ml 时为 95%）。对该提取物进行植物化学研究，分离出 11 种多环聚异戊二烯酰基间苯三酚 (PPAP)，其中 8 种显示出有效的抗疟原虫活性，IC50 范围为 3.3 μM 至 37.2 μM。 (C) 2008 Elsevier Ltd. 保留所有权利。
In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of Moronobea coccinea exhibited a strong antiplasmodial activity (95% at 10 mu g/ml). The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3 mu M to 37.2 mu M. (C) 2008 Elsevier Ltd. All rights reserved.