DUODENAL-ULCER - DISCOVERY OF A NEW MECHANISM AND DEVELOPMENT OF ANGIOGENIC THERAPY THAT ACCELERATES HEALING
DUODENAL-ULCER - DISCOVERY OF A NEW MECHANISM AND DEVELOPMENT OF ANGIOGENIC THERAPY THAT ACCELERATES HEALING
复制标题
DOI：
10.1097/00000658-199110000-00006
复制
发表时间：
1991-10-01
影响因子：
9
通讯作者：
SHING, Y
中科院分区：
文献类型：
--
作者：
FOLKMAN, J;SZABO, S;SHING, Y
第一个血管生成分子碱性成纤维细胞生长因子（bFGF）的完全纯化于1983年在作者的实验室进行。将这种肽应用于慢性伤口增强血管生成并加速伤口愈合。作者表明bFGF的酸稳定形式（即，bFGF-CS23）可以口服给予患有十二指肠溃疡的大鼠。该肽促进了溃疡床中血管生成的九倍增加，并且比西咪替丁更有效地加速溃疡愈合。碱性成纤维细胞生长因子不能减少胃酸。作者现在表明，bFGF作为一种天然存在的肽存在于大鼠和人的胃和十二指肠粘膜中。这种内源性碱性成纤维细胞生长因子也存在于大鼠慢性溃疡床中。硫糖铝结合bFGF并保护其免受酸降解。硫糖铝是血管生成，基于其对bFGF的亲和力。当硫糖铝口服给药大鼠，它显着提高碱性成纤维细胞生长因子的水平在溃疡床。西咪替丁，其能力，以减少胃酸，也提高了碱性成纤维细胞生长因子在溃疡床。提出了一个假设模型，其中通过常规疗法预防溃疡形成或加速溃疡愈合可能依赖于FGF。酸稳定性bFGF-CS23可被视为治疗十二指肠溃疡的一种替代疗法。
The complete purification of the first angiogenic molecule, basic fibroblast growth factor (bFGF), was carried out in the authors' laboratory in 1983. Application of this peptide to chronic wounds enhances angiogenesis and accelerates wound healing. The authors showed that an acid-stable form of bFGF (i.e., bFGF-CS23) could be administered orally to rats with duodenal ulcers. The peptide promoted a ninefold increase of angiogenesis in the ulcer bed and accelerated ulcer healing more potently than cimetidine. Basic fibroblast growth factor did not reduce gastric acid. The authors now show that bFGF exists as a naturally occurring peptide in rat and human gastric and duodenal mucosa. This endogenous bFGF is present also in the bed of chronic ulcers in rats. Sucralfate binds bFGF and protects it from acid degradation. The sucralfate is angiogenic, based on its affinity for bFGF. When sucralfate is administered orally to rats, it significantly elevates the level of bFGF in the ulcer bed. Cimetidine, by its capacity to reduce gastric acid, also elevates bFGF in the ulcer bed. A hypothetical model is proposed in which prevention of ulcer formation or accelerated healing of ulcers by conventional therapies may be FGF dependent. Acid-stable bFGF-CS23 may be considered as a form of replacement therapy in the treatment of duodenal ulcers.