The role of dietary n-6 and n-3 fatty acids in the developing brain
The role of dietary n-6 and n-3 fatty acids in the developing brain
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DOI：
10.1159/000017478
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发表时间：
2000-09-01
影响因子：
2.9
通讯作者：
Innis, SM
中科院分区：
文献类型：
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作者：
Innis, SM
必需脂肪酸的膳食需求和多不饱和脂肪酸二十二碳六烯酸(DHA)发挥特定作用的可能性是婴儿营养学中最有争议的领域之一。DHA在大脑中的浓度异常高，并在胎儿和婴儿的大脑发育过程中选择性地积累。从α-亚麻酸出发，通过一系列复杂的链延长-减饱和反应可以合成DHA，但这一过程在年轻婴儿中的效率尚不清楚。关于膳食DHA对神经发育的潜在益处的临床研究得出了相互矛盾的结果，最近的研究表明，血浆DHA对发育中的大脑是有效的，并且DHA参与了多巴胺和5-羟色胺的代谢。这些发现应该指导临床研究对饮食n-3脂肪酸的功能作用进行更敏感的测量，并指导n-3脂肪酸可能受益的临床条件，版权所有(C)2000 S.Karger AG，巴塞尔。
The dietary requirements for essential fatty acids and the possibility of a specific role for the polyunsaturated fatty acid docosahexaenoic acid (DHA) is one of the most controversial areas in infant nutrition. DHA is found in unusually high concentrations in the brain and is selectively accumulated during fetal and infant brain growth. DHA can be synthesised through a complex series of chain elongation-desaturation reactions from alpha -linolenic acid, but the efficiency of this process in young infants is not clear. Clinical studies on the potential benefits to neural development of dietary DHA have yielded conflicting results, Recent studies have provided evidence that plasma DHA is available to developing brain and that DHA is involved in dopamine and serotonin metabolism. These findings should guide clinical studies to more sensitive measures of the functional roles of dietary n-3 fatty acids and to clinical conditions where n-3 fatty acids may have benefit, Copyright (C) 2000 S. Karger AG, Basel.