Structure and organization of the RBMY genes on the human Y chromosome:: Transposition and amplification of an ancestral autosomal hnRNPG gene
Structure and organization of the RBMY genes on the human Y chromosome:: Transposition and amplification of an ancestral autosomal hnRNPG gene
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DOI：
10.1006/geno.1998.5255
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发表时间：
1998-04-15
期刊：
影响因子：
4.4
通讯作者：
Yen, PH
中科院分区：
文献类型：
--
作者：
Chai, NN;Zhou, HY;Yen, PH
RBMY（RNA结合基序，Y染色体）基因家族编码与精子发生有关的生殖细胞特异性核蛋白，它由大约30个基因和假基因组成，发现于Y染色体的两臂。RBMY与常染色体hnRNPG基因具有高度同源性，该基因含有RNA结合基序和在RBMY中发现的四个SRGY重复之一。一种观点认为，RBMY代表了一个祖先的hnRNPG基因，转座到Y染色体上，然后扩增。我们在Y染色体长臂的间隔6中鉴定了7个RBMY基因，其中4个具有正常结构，12个外显子，跨度15 kb，而1个缺少前3个外显子，因此代表假基因。其余两个基因属于不同的亚家族，类似于只有一个SRGY重复的常染色体hnRNPG基因。我们还发现，大多数RBMY基因在间隔6中串联排列。Y连锁RBMY基因的结构和组织支持转座扩增假说。(C)北京：科学出版社.
The RBMY (RNA-binding motif, Y chromosome) gene family encodes a germ-cell-specific nuclear protein implicated in spermatogenesis, It consists of approximately 30 genes and pseudogenes, found on both arms of the Y chromosome. RBMY shares high homology with an autosomal hnRNPG gene that contains an RNA-binding motif and one of the four SRGY repeats found in RBMY. One proposal is that RBMY represents an ancestral hnRNPG gene, transposed to the Y chromosome and then amplified. We characterized seven RBMY genes in interval 6 of the Y chromosome long arm. Four have the normal structure with 12 exons spanning 15 kb, whereas one lacks the first 3 exons, therefore representing a pseudogene. The remaining two genes belong to a different subfamily, resembling the autosomal hnRNPG gene with only one SRGY repeat, We also found that most RBMY genes in interval 6 are arranged in tandem. The structure and organization of the Y-linked RBMY genes support the transposition-amplification hypothesis. (C) 1998 Academic Press.