Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne
Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne
复制标题
南海海绵 Hippospongia lachne 中的新型抗真菌聚酮化合物 Hippolachnin A
DOI：
10.1021/ol400933x
复制
发表时间：
2013-07-19
期刊：
影响因子：
5.2
通讯作者：
Lin, Hou-Wen
中科院分区：
文献类型：
--
作者：
Piao, Shu-Juan;Song, Yun-Long;Lin, Hou-Wen
希波海绵素A（1）是从中国南海海绵Hippospongia lachne中分离得到的一种具有前所未有的四元环碳骨架的聚酮化合物。使用MS和NMR光谱分析来阐明结构，并且使用计算的ECD方法来确定绝对构型。Hippolachnin A对三种致病真菌，新生隐球菌，红色毛癣菌和石膏样小孢子菌表现出有效的抗真菌活性，每种真菌的MIC值为0.41 μ M。
Hippolachnin A (1), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge Hippospongia lachne. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 mu M for each fungus.