RECIPROCAL EFFECTS OF HYPERACTIVITY AND HYPOACTIVITY MUTATIONS IN THE DROSOPHILA PATTERN GENE TORSO
RECIPROCAL EFFECTS OF HYPERACTIVITY AND HYPOACTIVITY MUTATIONS IN THE DROSOPHILA PATTERN GENE TORSO
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DOI：
10.1126/science.2922596
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发表时间：
1989-02-24
期刊：
影响因子：
56.9
通讯作者：
LIPSHITZ, HD
中科院分区：
文献类型：
--
作者：
STRECKER, TR;HALSELL, SR;LIPSHITZ, HD
在果蝇中，雌性果蝇中必须有五个“末端”极性基因处于活跃状态，才能产生具有正常前后端的胚胎。其中一个这样的基因，躯干，低活性突变，导致fushi tarazu表达和终端表皮结构的最后域的损失。相反，躯干活动过度突变导致中央fushi tarazu表达和中央表皮结构的丧失。细胞质渗漏，移植，和温度变化的实验表明，后者的影响是由异常持久性的躯干产品在胚胎的中心区域在早期发展。因此，躯干活动的数量和时间是区分胚胎中央和末端区域的关键。无尾末端基因的突变作为过度活跃的躯干等位基因的显性母体抑制因子，表明躯干产物通过无尾产物起作用，或与无尾产物协同作用。
In Drosophila, five "terminal" polarity genes must be active in females in order for them to produce embryos with normal anterior and posterior ends. Hypoactivity mutations in one such gene, torso, result in the loss of the most posterior domain of fushi tarazu expression and the terminal cuticular structures. In contrast, a torso hyperactivity mutation causes the loss of central fushi tarazu expression and central cuticular structures. Cytoplasmic leakage, transplantation, and temperature-shift experiments suggest that the latter effect is caused by abnormal persistence of the torso product in the central region of the embryo during early development. Thus, the amount and timing of torso activity is key to distinguishing the central and terminal regions of the embryo. Mutations in the tailless terminal gene act as dominant maternal suppressors of the hyperactive torso allele, indicating that the torso product acts through, or in concert with, the tailless product.