A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO2 from an Oil Refinery
A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO2 from an Oil Refinery
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DOI：
10.3390/ijerph16061057
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发表时间：
2019-03-02
影响因子：
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通讯作者：
Biggeri, Annibale
中科院分区：
文献类型：
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作者：
Barbone, Fabio;Catelan, Dolores;Biggeri, Annibale
为了确定暴露于二氧化硫（SO2）对儿童呼吸功能的急性影响，我们在一家大型炼油厂附近进行了两次以人群为基础的纵向调查。我们在意大利Sarroch招募了233名8-14岁的儿童。第一项研究包括每月5次肺活量测定访问（组5）。在一个亚组中，呼吸道症状史呈阳性的儿童每周（20次）进行肺活量测定和呼气一氧化氮分数（FeNO）测量（小组20）。记录基线问卷和日常日记。监测SO2、NO2、PM10和o3。拟合了多元回归模型。使用多污染物模型，我们发现，在lag0-2天，10 μ g/m(3) SO2的增加决定了面板5中一秒钟后强制呼气量（FEV1）的百分比变化（PV）为-3.37(90%置信区间，CI: -5.39; -1.30)，面板20中的PV = -3.51 （90% CI: -4.77; -2.23）。我们发现了很强的剂量-响应关系：1-h SO2峰值>200 μ g/m(3)在lag2天= FEV1 PV -2.49。对于FeNO，我们发现在8小时的滞后时间内，每增加10 μ g/m(3) SO2, PV = 38.12 (90% CI: 12.88; 69.01)，并且有很强的剂量-响应关系。暴露于二氧化硫与肺功能降低和气道炎症增加密切相关。这一二氧化硫峰值有害影响的新证据应该引起监管干预。
To determine the acute effects on respiratory function of children exposed to sulphur dioxide (SO2), we conducted two population-based longitudinal investigations near a major oil refinery. We enrolled 233 children, age 8-14, in Sarroch (Italy). The first study entailed five monthly spirometric visits (Panel 5). In a subgroup, children positive for history of respiratory symptoms were tested weekly (20 times) with spirometry and fractional exhaled nitric oxide (FeNO) measurement (Panel 20). Baseline questionnaires and daily diaries were recorded. SO2, NO2, PM10 and O-3 were measured by monitoring stations. Multiple regression models were fitted. Using a multipollutant model, we found that a 10 mu g/m(3) SO2 increase at lag0-2 days determined a percent variation (PV) of -3.37 (90% confidence interval, CI: -5.39; -1.30) for forced expiratory volume after one second (FEV1) in Panel 5 and a PV = -3.51 (90% CI: -4.77; -2.23) in Panel 20. We found a strong dose-response relation: 1-h SO2 peaks >200 mu g/m(3) at lag2 days = FEV1 PV -2.49. For FeNO, we found a PV = 38.12 (90% CI: 12.88; 69.01) for each 10 mu g/m(3) SO2 increase at 8-h time lag and a strong dose-response relation. Exposure to SO2 is strongly associated with reduction of lung function and an increase in airway inflammation. This new evidence of harmful effects of SO2 peaks should induce regulatory intervention.