Increased choriocapillaris vessel density in amblyopic children: a case-control study
Increased choriocapillaris vessel density in amblyopic children: a case-control study
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DOI：
10.1016/j.jaapos.2018.04.005
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发表时间：
2018-10-01
期刊：
影响因子：
1.6
通讯作者：
Tsui, Irena
中科院分区：
文献类型：
--
作者：
Borrelli, Enrico;Lonngi, Marcela;Tsui, Irena
目的应用光学相干断层扫描血管造影（OCT-A）研究儿童弱视的绒毛膜毛细血管病变。方法使用OCT-A对弱视患者和年龄匹配的对照组进行前瞻性成像。OCT-A显示，从视网膜色素上皮后31 μ m处开始，绒毛膜毛细血管直径30 μ m。视网膜浅血管下的绒毛膜毛细血管切片被排除在分析之外，以避免阴影或投影伪影。主要结局指标为绒毛膜毛细血管密度。次要指标是黄斑中央凹厚度和黄斑中央凹旁厚度。结果16例弱视患者共20只眼，对照组25只眼。弱视受试者的平均年龄为7.6±3.6岁；对照组9.3±2.2岁（P = 0.10）。受试者平均屈光不正4.3 +/- 6.2 D；对照组为0.0 +/- 1.6 D （P = 0.004）。弱视组平均绒毛膜毛细血管密度为74.8 +/- 5.8，对照组为71.1 +/- 3.6，即使在调整年龄和屈光不正后仍有显著性差异（P = 0.012）。各组间黄斑中央凹厚度和黄斑旁厚度无显著差异；然而，即使在调整了年龄和屈光不正（分别为203 +/- 11 μ m和189 +/- 12 μ m）后，弱视眼的外中央凹旁黄斑厚度（内核层到视网膜色素上皮外边界的内边界）也明显大于对照眼。[p = 0.014])。结论：在我们的研究队列中，弱视的眼睛被发现有增加的绒毛膜毛细血管密度以及更大的外中央凹旁黄斑厚度，这可能是由于外视网膜成熟的改变。
PURPOSE To investigate the choriocapillaris in children with amblyopia, using optical coherence tomography angiography (OCT-A).METHODS Patients with amblyopia and age-matched controls were prospectively imaged using OCT-A. On OCT-A, the choriocapillaris measures 30 mu m starting 31 mu m posterior to the retinal pigment epithelium. The section of choriocapillaris under superficial retinal vessels was excluded from analysis to avoid shadowing or projection artifacts. The main outcome measure was choriocapillaris vessel density. Secondary outcome measures were foveal macular thickness and parafoveal macular thickness.RESULTS A total of 20 eyes of 16 patients with amblyopia and 25 eyes of 25 controls were included. Mean age of amblyopic subjects was 7.6 +/- 3.6 years; of controls, 9.3 +/- 2.2 years (P = 0.10). Mean refractive error of subjects was 4.3 +/- 6.2 D; of controls, 0.0 +/- 1.6 D (P = 0.004). Mean choriocapillaris vessel density was 74.8 +/- 5.8 in the amblyopic group and 71.1 +/- 3.6 in the control group, which was significant even after adjusting for age and refractive error (P = 0.012). There was no difference between groups in foveal macular thickness or parafoveal macular thickness; however, outer parafoveal macular thickness (the inner boundary of the inner nuclear layer to the retinal pigment epithelium outer boundary) was significantly greater in amblyopic eyes than in control eyes, even after adjusting for age and refractive error (203 +/- 11 mu m and 189 +/- 12 mu m, resp. [P = 0.014]).CONCLUSIONS In our study cohort, amblyopic eyes were found to have increased choriocapillaris vessel density as well as a greater outer parafoveal macular thickness, which may be due to alterations in outer retinal maturation.