Assessment of tidal breathing parameters in infants with cystic fibrosis
Assessment of tidal breathing parameters in infants with cystic fibrosis
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DOI：
10.1183/09031936.03.00024703
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发表时间：
2003-11-01
影响因子：
24.3
通讯作者：
Stocks, J
中科院分区：
文献类型：
--
作者：
Ranganathan, SC;Goetz, I;Stocks, J
需要简单的方法来评估囊性纤维化（CF）婴儿的肺功能。这项研究确定了从潮式呼吸获得的简单测量值与从更复杂的用力呼气操作获得的测量值之间的关系。健康婴儿和患有囊性纤维化的婴儿分别从两个产科单位和五家囊性纤维化专科医院招募。测量镇静婴儿的呼吸频率、潮气量、每分钟通气量和潮气呼吸比（TPTEF:TE），并与提高容量技术测量的0.4秒用力呼气量（FEV0.4）进行比较。总共招募了95名健康婴儿和47名CF婴儿，年龄、性别、种族和母亲吸烟暴露比例相似。健康婴儿和 CF 婴儿之间的 TPTEF:TE 和潮气量没有差异。由于呼吸频率平均（95%置信区间）增加5.8（3.2-8.4）分钟（-1），CF婴儿的每分钟通气量显着增加。 13 名 (28%) 患有 CF 的婴儿呼吸频率升高 >2 SD。然而，无法确定呼吸频率与 FEV0.4 之间的关联。潮气呼吸比对于识别囊性纤维化婴儿的气道功能减弱没有帮助。呼吸频率升高可能部分是由于通气不均匀性造成的，但很难预测通过用力呼气测量到的气道功能减弱。
Simple methods are needed to assess lung function in infants with cystic fibrosis (CF). This study determined the relationship between simple measurements obtained from tidal breathing with those from more complicated forced expiratory manoeuvres.Healthy infants and infants with CF were recruited from two maternity units and five specialist CF hospitals, respectively. Respiratory rate, tidal volume, minute ventilation and the tidal breathing ratio (TPTEF:TE) were measured in sedated infants and compared with forced expiratory volume in 0.4 seconds (FEV0.4) measured by the raised volume technique.Altogether, 95 healthy infants and 47 infants with CF of similar age, sex, ethnicity and proportion exposed to maternal smoking were recruited. There was no difference in TPTEF:TE and tidal volume between healthy infants and those with CF. Minute ventilation was significantly greater in infants with CF due to a mean (95% confidence interval) increase in respiratory rate of 5.8 (3.2-8.4) min(-1). Thirteen (28%) infants with CF had a respiratory rate elevated by >2 SD. However, no association between respiratory rate and FEV0.4 could be identified.Tidal breathing ratio was not useful in identifying diminished airway function in infants with cystic fibrosis. An elevated respiratory rate may be due in part to ventilation heterogeneity but is poorly predictive of diminished airway function measured by forced expiration.