Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings
Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings
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DOI：
10.1016/s0039-128x(01)00180-5
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发表时间：
2002-05-01
期刊：
影响因子：
2.7
通讯作者：
Pace, M
中科院分区：
文献类型：
--
作者：
Thomas, P;Zhu, Y;Pace, M
鱼类卵母细胞成熟的内分泌控制已被证明是一个有价值的模型，用于研究细胞表面的快速，非基因组类固醇作用。在过去的十年中，已经取得了相当大的进展，在确定和表征介导这些行动的鱼，在了解这些受体在卵母细胞成熟的激素调节和生理作用，在阐明它们激活的信号转导途径，并确定其性质。简要回顾了这些问题的最新进展。新的数据表明百日咳毒素敏感的抑制性G蛋白在诱导卵母细胞成熟的成熟诱导类固醇（MIS）在硬骨鱼类的参与。此外，还讨论了从斑叶蜂卵巢中分离MIS受体基因的克隆策略，以及通过这种方法发现的新基因和蛋白质的特性。目前的证据表明，这种G-蛋白偶联受体样蛋白是长期寻求后MIS受体介导的减数分裂成熟的硬骨鱼卵母细胞。(C)2002年爱思唯尔科技有限公司All rights reserved.
The endocrine control of oocyte maturation in fish has proven to be a valuable model for investigating rapid, nongenomic steroid actions at the cell surface. Considerable progress has been made over the last decade in identifying and characterizing progestin membrane receptors mediating these actions in fish, in understanding the hormonal regulation and physiological roles of these receptors in oocyte maturation, in elucidating the signal transduction pathways they activate, and in determining their nature. Recent advances on these topics are briefly reviewed. New data demonstrating the involvement of pertussis toxin-sensitive inhibitory G-proteins in induction of oocyte maturation by the maturation-inducing steroid (MIS) in teleosts is also presented. In addition, the cloning strategy to isolate the MIS receptor gene from spotted seatrout ovaries and the characteristics of a novel gene and protein discovered by this approach are discussed. Current evidence suggests this G-protein-coupled receptor-like protein is the long sought after MIS receptor mediating meiotic maturation of teleost oocytes. (C) 2002 Elsevier Science Inc. All rights reserved.