Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy.
Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy.
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成功使用碘和左旋甲状腺素治疗放射性碘治疗后对抗甲状腺药物和高促甲状腺素结合抑制剂免疫球蛋白过敏的妊娠患者格雷夫斯病。
DOI：
10.1089/thy.2005.15.1373
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
A. Miyauchi
中科院分区：
文献类型：
--
作者：
S. Kubota;H. Ohye;I. Sasaki;E. Nishihara;Takumi Kudo;S. Fukata;N. Amino;K. Kuma;N. Mitsuda;A. Miyauchi
Graves病患者高滴度的促甲状腺素结合抑制剂免疫球蛋白（TBII）可导致妊娠期胎儿甲状腺功能亢进。曾有报告称，对既往接受过消融治疗的妊娠患者给予抗甲状腺药物（ATD）和左旋甲状腺素（LT（4））可预防胎儿甲状腺功能亢进。我们在妊娠期给一名患者服用碘和LT（4），因为她对ATD有严重的不良反应。虽然妊娠正常进行，婴儿表现出短暂的新生儿甲状腺功能亢进症后出生。我们认为，如果我们没有给母亲服用碘，胎儿会患上甲状腺功能亢进症。在对ATD过敏的罕见患者中，应考虑对经消融治疗后显示高TBII的妊娠Graves病患者给予碘和LT（4）。
High titer of thyrotropin-binding inhibitor immunoglobulin (TBII) in patients with Graves' disease can cause fetal hyperthyroidism during pregnancy. Prevention of fetal hyperthyroidism by administration of antithyroid drug (ATD) and levothyroxine (LT(4)) to pregnant patients who previously received ablative therapy has been reported. We administered iodine and LT(4) to a patient during gestation, because she had a severe adverse reaction to ATD. Although gestation proceeded normally, the infant showed transient neonatal hyperthyroidism right after birth. We believe that the fetus would have developed hyperthyroidism if we had not administered iodine to the mother. Administration of iodine and LT(4) to a pregnant patient with Graves' disease showing a high TBII after ablative therapy should be considered in rare patients with allergy to ATD.
影响甲状腺功能的激素和药物的胎盘运输、合成和代谢。
影响因子：
20.3
作者：
Roti,E;Gnudi,A;Braverman,LE
通讯作者：
Braverman,LE