Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C]PBR28 PET correlates with vascular disease measures.
Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C]PBR28 PET correlates with vascular disease measures.
复制标题
通过 [11C]PBR28 PET 评估，COVID-19 (PASC) 急性后遗症中的神经炎症与血管疾病指标相关。
DOI：
10.1101/2023.10.19.563117
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Loggia,MarcoL
中科院分区：
文献类型：
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作者：
VanElzakker,MichaelB;Bues,HannahF;Brusaferri,Ludovica;Kim,Minhae;Saadi,Deena;Ratai,Eva-Maria;Dougherty,DarinD;Loggia,MarcoL
由SARS-CoV-2引起的COVID-19大流行引发了相应的COVID-19急性后遗症（PASC）公共卫生危机，有时被称为长期COVID。构成PASC的异质性持续症状和体征的机制正在研究中，一些研究指出中枢神经和血管系统是功能障碍的潜在部位。在目前的研究中，我们招募了具有不同症状的PASC患者，并检查了神经炎症和血管功能障碍的循环标志物之间的关系。我们使用[11 C] PBR 28 PET神经成像，神经炎症的标志物，比较12个PASC个体和43个正常健康对照。我们发现PASC与对照组相比，在广泛的大脑区域，包括中扣带和前扣带皮层，胼胝体，丘脑，基底神经节和脑室边界，神经炎症显著增加，我们还收集和分析了PASC个体的外周血血浆，发现神经炎症与血管功能障碍相关的几种循环分析物之间存在显著的正相关性。这些结果表明，神经炎症和血管健康之间的相互作用可能有助于PASC的常见症状。
The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship between neuroinflammation and circulating markers of vascular dysfunction. We used [11C]PBR28 PET neuroimaging, a marker of neuroinflammation, to compare 12 PASC individuals versus 43 normative healthy controls. We found significantly increased neuroinflammation in PASC versus controls across a wide swath of brain regions including midcingulate and anterior cingulate cortex, corpus callosum, thalamus, basal ganglia, and at the boundaries of ventricles.We also collected and analyzed peripheral blood plasma from the PASC individuals and found significant positive correlations between neuroinflammation and several circulating analytes related to vascular dysfunction. These results suggest that an interaction between neuroinflammation and vascular health may contribute to common symptoms of PASC.