Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
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DOI：
10.1158/2159-8290.cd-20-0422
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发表时间：
2020-06-01
期刊：
影响因子：
28.2
通讯作者：
Cai, Hongbing
中科院分区：
文献类型：
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作者：
Dai, Mengyuan;Liu, Dianbo;Cai, Hongbing
截至二零二零年三月，新型COVID-19疫情已影响超过200个国家及地区。鉴于癌症患者通常更容易受到感染，因此需要对受COVID-19影响的不同癌症患者队列进行系统分析。我们进行了一项多中心研究，包括105名癌症患者和536名年龄匹配的非癌症患者。我们的研究结果显示，COVID-19癌症患者在所有严重结局中的风险更高。血液癌、肺癌或转移性癌症（IV期）患者的重度事件频率最高。非转移性癌症患者出现严重疾病的频率与非癌症患者相似。接受手术的患者发生严重事件的风险更高，而仅接受放疗的患者与未患癌症的患者相比，在严重事件方面没有显着差异。这些研究结果表明，癌症患者似乎更容易受到SARS-CoV-2爆发的影响。意义：因为这是关于这一主题的第一个大型队列研究，我们的报告将提供急需的信息，使全球癌症患者受益。因此，我们认为广泛传播我们的研究以提醒临床医生和患者是非常重要的。
The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally more vulnerable to infections, systematic analysis of diverse cohorts of patients with cancer affected by COVID-19 is needed. We performed a multicenter study including 105 patients with cancer and 536 age-matched noncancer patients confirmed with COVID-19. Our results showed COVID-19 patients with cancer had higher risks in all severe outcomes. Patients with hematologic cancer, lung cancer, or with metastatic cancer (stage IV) had the highest frequency of severe events. Patients with nonmetastatic cancer experienced similar frequencies of severe conditions to those observed in patients without cancer. Patients who received surgery had higher risks of having severe events, whereas patients who underwent only radiotherapy did not demonstrate significant differences in severe events when compared with patients without cancer. These findings indicate that patients with cancer appear more vulnerable to SARS-CoV-2 outbreak.SIGNIFICANCE: Because this is the first large cohort study on this topic, our report will provide much-needed information that will benefit patients with cancer globally. As such, we believe it is extremely important that our study be disseminated widely to alert clinicians and patients.