Higher cortisol levels may proceed a manic episode and are related to disease severity in patients with bipolar disorder.
Higher cortisol levels may proceed a manic episode and are related to disease severity in patients with bipolar disorder.
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较高的皮质醇水平可能会导致躁狂发作，并且与双相情感障碍患者的疾病严重程度相关。
DOI：
10.1016/j.psyneuen.2020.104658
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发表时间：
2020
影响因子：
3.7
通讯作者：
Spijker,AnneT
中科院分区：
文献类型：
--
作者：
vandenBerg,MoniqueT;Wester,VincentL;Vreeker,Annabel;Koenders,ManjaA;Boks,MarcoP;vanRossum,ElisabethFC;Spijker,AnneT
研究背景下丘脑-垂体-肾上腺（HPA）轴的调节参与双相情感障碍（BD）的发病机制。然而，HPA活性和疾病严重程度之间的关系尚未完全阐明。在这项初步研究中，我们的目的是探讨HPA活性和躁狂发作的风险在BD患者I型之间的时间关系，通过评估长期的头发皮质醇浓度（HCC）。第二，我们探讨了肝癌和以前的episodes.MethodsHair样本的数量之间的关系，收集了45 BD I患者在euthymic或躁狂状态，并与17个对照。从每个参与者，两个头发样本的3厘米长被用来测量长期皮质醇，反映回顾时间框架1-3个月和4-6个月前sampling.ResultsHCC在BD组略高于对照组在两个头发段（p = 0.049和0.03;调整年龄、性别、BMI和洗发频率后，p = 0.222和0.139）。在躁狂发作之前观察到毛发皮质醇的显著峰值（p = 0.036）。此外，我们发现情绪发作HCC（p = 0.03）。ConclusionsOur结果表明，长期皮质醇水平略高，BD，特别是在躁狂复发前几个月升高之间的正相关性。此外，HCC与BD I型病程中既往情绪发作次数呈正相关。
BackgroundRegulation of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the pathogenesis of bipolar disorder (BD). However, the relationship between HPA-activity and disease severity is not fully elucidated. In this pilot study we aimed to explore the temporal relationship between HPA-activity and the risk of a manic episode in BD patients type I, by assessing long-term hair cortisol concentrations (HCC). Second, we explored the relation between HCC and the number of previous episodes.MethodsHair samples were collected from 45 BD I patients in euthymic or manic state and compared to 17 controls. From each participant, two hair samples of 3 cm length were used to measure long-term cortisol, reflecting retrospect time frames of 1–3 months and 4–6 months respectively prior to sampling.ResultsHCC in the BD group was slightly higher than in the control group in both hair segments (p = 0.049 and 0.03; after adjustment for age, sex, BMI and hair washing frequency p = 0.222 and 0.139). A significant peak in hair cortisol was observed prior to a manic episode (p = 0.036). Furthermore, we found a positive correlation between the number of mood episodes HCC (p = 0.03).ConclusionsOur results indicate that long-term cortisol levels are slightly higher in BD, and in particular elevated in the months prior to a manic relapse. In addition HCC are positively associated with the number of previous mood episodes in the course of BD type I.