Regional brain volume abnormalities and long-term cognitive outcome in preterm infants
Regional brain volume abnormalities and long-term cognitive outcome in preterm infants
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DOI：
10.1001/jama.284.15.1939
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发表时间：
2000-10-18
影响因子：
120.7
通讯作者：
Ment, LR
中科院分区：
文献类型：
--
作者：
Peterson, BS;Vohr, B;Ment, LR
背景 早产儿长期认知和行为障碍的患病率很高。然而，目前尚不清楚与早产相关的压力是否会破坏特定区域的大脑成熟，或者大脑结构的异常是否会导致认知缺陷。目的确定足月儿和早产儿之间的区域脑容量是否存在差异，并检查早产儿的区域脑容量与长期认知结果的关系。设计和设置1998年和1999年在美国两所大学医学院进行的病例对照研究。参与者招募了25名8岁早产儿的连续样本来自对早产儿和 39 名足月对照儿童的纵向随访研究，这些儿童是从社区招募的，在年龄、性别、孕产妇教育和少数民族状况方面与早产儿具有可比性。主要结果指标是皮质分区、心室系统、小脑、基底神经节、胼胝体、杏仁核和海马体的体积，来自结构磁共振成像扫描，并在早产儿和足月之间进行比较儿童；早产儿的区域脑容量与认知测量（8 岁时）和围产期变量的相关性。 结果 早产儿的区域皮质体积显着较小，尤其是感觉运动区（差异：左，14.6%；右，14.3% [P
Context Preterm infants have a high prevalence of long-term cognitive and behavioral disturbances. However, it is not known whether the stresses associated with premature birth disrupt regionally specific brain maturation or whether abnormalities in brain structure contribute to cognitive deficits.Objective To determine whether regional brain volumes differ between term and preterm children and to examine the association of regional brain volumes in prematurely born children with long-term cognitive outcomes.Design and Setting Case-control study conducted in 1998 and 1999 at 2 US university medical schools.Participants A consecutive sample of 25 eight-year-old preterm children recruited from a longitudinal follow-up study of preterm infants and 39 term control children who were recruited from the community and who were comparable with the preterm children in age, sex, maternal education, and minority status.Main Outcome Measures Volumes of cortical subdivisions, Ventricular system, cerebellum, basal ganglia, corpus callosum, amygdala, and hippocampus, derived from structural magnetic resonance imaging scans and compared between preterm and term children; correlations of regional brain volumes with cognitive measures (at age 8 years) and perinatal variables among preterm children.Results Regional cortical volumes were significantly smaller in the preterm children, most prominently in sensorimotor regions (difference: left, 14.6%; right, 14.3% [P