Circulating CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells as Potential Biomarkers for the Identification of Psoriasis TCM Blood-Heat Syndrome and Blood-Stasis Syndrome
Circulating CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells as Potential Biomarkers for the Identification of Psoriasis TCM Blood-Heat Syndrome and Blood-Stasis Syndrome
复制标题
循环CD14( )HLA-DR-/低髓源性抑制细胞作为银屑病中医血热证和血瘀证潜在生物标志物
DOI：
10.1155/2020/4582459
复制
发表时间：
2020-04-15
影响因子：
--
通讯作者：
Liu, Guijian
中科院分区：
文献类型：
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作者：
Sun, Shipeng;Wei, Yali;Liu, Guijian
牛皮癣是一种慢性自身免疫性疾病。识别银屑病中医证候的生物标志物有助于研究人员认识银屑病的不同方面，并为银屑病的治疗找到新的治疗靶点。本研究观察了不同中医证型银屑病患者外周血中Mo-MDSCs和Mo-MDSC相关免疫因子的水平。我们发现斑块型银屑病血瘀证患者CD14(+)细胞中Mo-MDSCs(CD14(+)人类白细胞抗原-DR-/低细胞)的频率明显高于健康对照组(mfenceClose=“)”OPEN=“(”分离器=“|”p
Psoriasis is a chronic autoimmune disease. Identification of the biomarkers responsible for Traditional Chinese Medicine (TCM) syndromes of psoriasis can help researchers recognize the different aspects of psoriasis and find novel therapeutic targets for the treatment of psoriasis. The current study investigated the levels of circulating Mo-MDSCs and Mo-MDSC-associated immune factors in the peripheral blood of psoriasis patients with different TCM syndromes. We found that the frequency of Mo-MDSCs (CD14(+)HLA-DR-/low cells) among CD14(+) cells from plaque psoriasis patients with blood-stasis (BS) syndrome was significantly increased when compared with healthy controls mml:mfenced close=")" open="(" separators="|"p