VENTILATION DURING SLEEP ONSET
VENTILATION DURING SLEEP ONSET
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DOI：
10.1152/jappl.1987.63.5.2067
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发表时间：
1987-11-01
影响因子：
3.3
通讯作者：
WILSON, GV
中科院分区：
文献类型：
--
作者：
COLRAIN, IM;TRINDER, J;WILSON, GV
现在有相当多的证据表明，睡眠时的呼吸活动与清醒时不同。然而，在从清醒到睡眠的过渡期间，呼吸变化的研究很少。本研究关注的是睡眠开始时通气的定量和时间特性。在一系列单一受试者设计中，研究了5名年轻男性的睡眠开始，其中睡眠开始是重复的。结果表明，在睡眠开始期间，α-脑电图中的活动与通气量的大量、快速和高度可预测的减少相关。通气量的变化通常是由于潮气量减少，部分继发于代谢率降低。我们推测，非代谢成分可能反映了清醒时呼吸神经驱动的丧失，尽管目前的研究没有排除各种其他解释。
There is now considerable evidence which indicates that respiratory activity is different during sleep compared with wakefulness. However, there has been little work on respiratory changes during the transitional period from wakefulness to sleep. The present study was concerned with the quantitative and temporal properties of ventilation during sleep onset. Sleep onsets were studied in five young male adults in a series of single-subject designs in which sleep onsets were replications. The results indicated that during sleep onset the loss of .alpha.-activity in the electroencephalogram was associated with a substantial, rapid, and highly predictable reduction in ventilation. The change in ventilation was typically due to a reduction in tidal volume and was, in part, secondary to a reduction in metabolic rate. We spectulate that the nonmetabolic component may reflect the loss of waking neural drive to respiration, though the present study did not eliminate a variety of other interpretations.