Corpus Christi strain-induced protection to Trypanosoma cruzi infection in C3H(He) mice: effective dose, time, route, and number of vaccinations.
Corpus Christi strain-induced protection to Trypanosoma cruzi infection in C3H(He) mice: effective dose, time, route, and number of vaccinations.
复制标题
Corpus Christi菌株对C3H(He)小鼠克氏锥虫感染的保护作用：有效剂量、时间、途径和疫苗接种次数。
作者：
D. Ritter;E. Rowland
本文报道了影响科珀斯克里斯蒂菌株诱导C3H（He）小鼠对巴西克氏t型病毒感染保护作用的参数。研究发现，10(7)剂的剂量是最有效的保护剂量。在小鼠感染前5天至11周接种疫苗被确定为保护的最佳时间间隔。皮下接种和感染途径为实验动物提供了最有效的保护。多次接种科珀斯克里斯蒂，无论是活的还是冻融的，都只略微增加了保护效果。科珀斯克里斯蒂克氏体菌株已被证明非常适合为高度敏感的C3H（He）小鼠提供保护，使其免受克氏体巴西毒株的感染。
The study of the parameters affecting Corpus Christi strain-induced protection in C3H(He) mice against Brazil strain T. cruzi infection is reported herein. A dose of 10(7) Corpus Christi epimastigotes was found to be the most effective dose for protection. Vaccination of mice 5 days to 11 wk prior to infection was determined to be the optimal time interval for protection. The subcutaneous route for vaccination and infection provides the most effective protection to experimental animals. Multiple inoculations with Corpus Christi, whether live or freeze thawed, increased the protective effect only slightly. The Corpus Christi strain of T. cruzi has proved to be quite suitable in providing protection to highly susceptible C3H(He) mice against an infection with the virulent Brazil strain of T. cruzi.