Serotonin and stress
Serotonin and stress
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DOI：
10.1016/s0893-133x(99)00008-1
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发表时间：
1999-08-01
影响因子：
7.6
通讯作者：
Mormède, P
中科院分区：
文献类型：
--
作者：
Chaouloff, F;Berton, O;Mormède, P
大脑血清素 (5-HT) 被发现 45 年后，仍然是深入研究的主题，旨在了解 5-羟色胺在压力适应中的作用。在突触前水平，许多应激源会增加血清素能细胞体或神经末梢水平的神经放电和细胞外 5-HT。不同的研究报告了细胞外 5-HT 的应激源和区域特异性变化，这一观点受到电生理学和神经化学证据的挑战，即当考虑到活动/唤醒时，血清素能神经元对应激源的非特异性反应。此外，早期研究表明，压力引起的 5-HT 合成升高是由特定的神经内分泌机制介导的，5-HT 合成是实现血清素稳态的关键反调节过程。除了突触后 5-HT 受体的多样性及其受皮质激素的特异性调节之外，在考虑一种受体类型（例如 5-HT1A 受体）时，还强调了对应激源的特异性。压力研究应考虑个人过去的经历和遗传状况，将其作为对压力的血清素反应的关键调节剂。 (C) 1999 年美国神经精神药理学学院。由爱思唯尔科学公司出版
Forty-five years after its discovery, brain serotonin (5-HT) is still the subject of intense research aimed at understanding ifs role in stress adaptation. At the presynaptic level, numerous stressors increase nerve firing and extracellular 5-HT at the level of serotonergic cell bodies or nerve terminals. Different studies have reported stressor- and region-specific changes in extracellular 5-HT, a view challenged by electrophysiological and neurochemical evidence for a nonspecific response of serotonergic neurones to stressors when activity/arousal is taken into account. In addition, early studies indicate that stress-induced elevation in 5-HT synthesis, a key counter-regulatory process allowing serotonergic homeostasis, is mediated by specific neuroendocrine mechanisms. In addition to the multiplicity of postsynaptic 5-HT receptors and their specific regulation by corticoids, specificity to stressors is also underscored when considering one receptor type such as the 5-HT1A receptor. Stress studies should consider the past experience and the genetic status of the individual as key modulators oft he serotonergic responses to stress. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.