Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program.
Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program.
复制标题
DOI：
10.1053/j.gastro.2020.07.011
复制
发表时间：
2020-11
期刊：
影响因子：
29.4
通讯作者：
中科院分区：
文献类型：
--
作者：
一些指南建议非洲裔美国人在50岁之前开始结直肠癌（CRC）筛查，但很少有数据表明该人群的筛查吸收和收益。我们在Kaiser Permanente北加州健康计划的非裔美国人成员中进行了粪便免疫化学试验（FIT）筛查的前瞻性研究。我们将2018年45-50岁（早期筛查组）的非裔美国人成员的数据与先前未筛查的51-56岁的非裔美国人、白人、西班牙裔和亚洲/太平洋岛民健康计划成员的数据进行了比较。使用邮寄的FIT试剂盒进行筛查外展。采用经性别调整的Logistic回归模型，评估各组在筛查摄取、异常检查结果的结肠镜随访和检查结果方面的差异。在10,232名早期筛查组的非裔美国人中，通过邮寄FIT，筛查完成率为33.1%。在4%的阳性检测结果中，85.3%完成了结肠镜随访，57.8%患有腺瘤，33.6%患有晚期腺瘤（腺瘤具有晚期组织学或息肉≥10 mm）， 2.6%被诊断为结直肠癌。早期筛查组的非裔美国人完成筛查的可能性略高于先前未筛查的非裔美国人、白人和51-56岁的西班牙裔。两组在FIT阳性结果方面没有显著差异（范围，3.8%-4.6%），超过74%的患者在检测结果阳性后接受了随访结肠镜检查。任何腺瘤（范围56.7%-70.7%）、晚期腺瘤（范围20.0%-33.6%）和结直肠癌（范围0 - 7.1%）的检测结果相似。参与早期（45-50岁）FIT筛查的非洲裔美国人的比例和检测结果与先前未接受筛查的非洲裔美国人、白人、西班牙裔美国人和51-56岁的亚洲/太平洋岛民相当。指南建议非洲裔美国人在45岁时开始结肠直肠癌筛查。45-50岁的非洲裔美国人对邮寄的粪便免疫化学测试的反应与51-56岁之前未进行筛查的人的测试完成度和结直肠生长率相似。
Some guidelines recommend starting colorectal cancer (CRC) screening before age 50 years for African Americans, but there are few data on screening uptake and yield in this population. We performed a prospective study of fecal immunochemical test (FIT) screening among African American members of the Kaiser Permanente Northern California health plan. We compared data from African American members screened when they were 45–50 years old (early screening group) in 2018 with data from previously unscreened African American, white, Hispanic, and Asian/Pacific Islander health plan members, 51–56 years old. Screening outreach was performed with mailed FIT kits. Logistic regression models, adjusted for sex, were used to evaluate differences among groups in screening uptake, colonoscopy follow up of abnormal test results, and test yield. Among 10,232 African Americans in the early screening group who were mailed a FIT, screening was completed by 33.1%. Among the 4% with positive test results, 85.3% completed a follow-up colonoscopy: 57.8% had any adenoma, 33.6% had an advanced adenoma (adenoma with advanced histology or polyp ≥10 mm), and 2.6% were diagnosed with CRC. African Americans in the early screening group were modestly more likely to have completed screening than previously unscreened African Americans, whites, and Hispanics 51–56 years old. The groups did not differ significantly in positive results from the FIT (range, 3.8%–4.6%) and more than 74% received a follow-up colonoscopy after a positive test result. The test yields for any adenoma (range, 56.7%–70.7%), advanced adenoma (range, 20.0%–33.6%), and CRC (range, 0 to 7.1%) were similar. Proportions of African Americans who participated in early (ages 45–50 years) FIT screening, and test yield, were comparable to those of previously unscreened African Americans, whites, Hispanics, and Asian/Pacific islanders who were 51–56 years old. Guidelines recommend African Americans begin colorectal screening at age 45 years. African Americans 45–50 years old responded to mailed fecal immunochemical tests with similar test completion and yield of colorectal growths as people 51–56 years old who had not been screened before.
登录
查看更多内容
影响因子：
120.7
作者：
Corley, Douglas A.;Jensen, Christopher D.;Levin, Theodore R.
通讯作者：
Levin, Theodore R.
DOI：
10.1056/nejmoa1100370
发表时间：
2012-02-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Zauber AG;Winawer SJ;O'Brien MJ;Lansdorp-Vogelaar I;van Ballegooijen M;Hankey BF;Shi W;Bond JH;Schapiro M;Panish JF;Stewart ET;Waye JD
通讯作者：
Waye JD
DOI：
10.1056/nejmoa1309086
发表时间：
2014-04-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Corley DA;Jensen CD;Marks AR;Zhao WK;Lee JK;Doubeni CA;Zauber AG;de Boer J;Fireman BH;Schottinger JE;Quinn VP;Ghai NR;Levin TR;Quesenberry CP
通讯作者：
Quesenberry CP
影响因子：
39.2
作者：
Brenner, Hermann;Chang-Claude, Jenny;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael
影响因子：
3.6
作者：
Williams R;White P;Nieto J;Vieira D;Francois F;Hamilton F
通讯作者：
Hamilton F