The OFF-pathway dominance of P2X2-purinoceptors is formed without visual experience
The OFF-pathway dominance of P2X2-purinoceptors is formed without visual experience
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DOI：
10.1016/j.neures.2009.09.1714
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发表时间：
2010-01-01
影响因子：
2.9
通讯作者：
Shimoda, Yukio
中科院分区：
文献类型：
--
作者：
Kaneda, Makoto;Ito, Koichi;Shimoda, Yukio
关键期的视觉输入是视觉系统功能的重要决定因素，例如影响视皮层中眼优势柱的形成。柱状组织的最终图通常是由关键时期的塑性变化决定的，但在没有足够的视觉输入的情况下，组织是扭曲的。在这里，我们研究了在小鼠视网膜中P2 X（2）-嘌呤受体信号传导的OFF通路优势的形成是否是视觉体验的结果。P2 X（2）-嘌呤受体信号通路在此关键期发育。然而，在这一时期的视觉体验中，P2 X（2）-嘌呤受体信号传导的OFF通路优势的形成没有产生可塑性变化。我们的研究结果表明，在小鼠视网膜中，P2 X（2）信号的OFF通路优势是内在编程的。(C)2009年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
Visual input in the critical period is an important determinant of the functions of the visual system, affecting for example the formation of the ocular dominance column in the visual cortex. The final map of columnar organization is usually determined by plastic changes in the critical period, but organization is distorted without adequate visual input. Here, we examined whether formation of the OFF-pathway dominance of P2X(2)-purinoceptor signaling in the mouse retina is the result of visual experience. The P2X(2)-purinoceptor signaling pathway developed during the critical period. However, visual experience in this period produced no plastic change in the formation of the OFF-pathway dominance of P2X(2)-purinoceptor signaling. Our findings suggest that the OFF-pathway dominance of P2X(2)-signaling in the mouse retina is intrinsically programmed. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.