NAEVI AND MELANOMATA OF THE CONJUNCTIVA*†
NAEVI AND MELANOMATA OF THE CONJUNCTIVA*†
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结膜的痣和黑色素瘤*†
DOI：
10.1136/bjo.49.4.169
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发表时间：
1965
影响因子：
4.1
通讯作者：
B. Jay
中科院分区：
文献类型：
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作者：
B. Jay
恶性黑色素瘤是最常见的结膜良性肿瘤，恶性黑色素瘤是眼部最严重的肿瘤之一。在典型病例中，色素痣和黑色素瘤的组织学诊断并不困难，但许多病例并不典型，正是这些非典型病例削弱了组织病理学家的诊断能力，特别是当病变显示出提示恶性的变化时。除了这些肿瘤带来的诊断问题外，他们的治疗也存在争议，主要是因为，除了某些值得注意的例外，很少有临床医生在他们的有生之年治疗过超过一定数量的这些肿瘤。伦敦眼科研究所病理科收集了大量这些肿瘤，为澄清结膜黑色素性损害的某些方面提供了机会，为此，重新检查了1948至1961年间转诊到病理科的所有痣和恶性黑色素瘤，并对其组织学诊断进行了确认或调整。此外，所有被诊断为恶性、恶性前期或可能恶性黑色素瘤的病例，如果患者曾到Moorfield眼科医院就诊，则通过参考医院记录进行随访，如果患者曾到其他医院就诊，则通过写信给转诊外科医生或病理学家进行跟进。这项研究的目的有三个。首先，根据公认的命名和对400个此类肿瘤的组织学检查结果，对结膜痣和恶性黑色素瘤进行分类。第二，确定那些直接恶性的肿瘤和那些显示出暗示恶性的变化的肿瘤的恶性程度。第三，比较结膜色素痣和恶性黑色素瘤与皮肤的组织学表现。
NAEvi are the most common benign tumours of the conjunctiva, and their malignant counterparts, the malignant melanomata, although far less frequently encountered, are among the most serious of the ocular neoplasms. In typical cases the histological diagnosis of naevi and melanomata is not difficult, but many cases are not typical, and it is these atypical cases that tax the diagnostic ability of the histopathologist, particularly if the lesion shows changes suggestive of malignancy. In addition to the diagnostic problems presented by these tumours their treatment is in dispute, mainly because, with certain notable exceptions, few clinicians have treated more than a smnall number of these tumours during their lifetime. The large collection of these tumours in the Department of Pathology at the Institute of Ophthalmology, London, presented an opportunity for clarifying certain aspects of melanotic lesions of the conjunctiva, and to this end all the naevi and malignant melanomata referred to the Department of Pathology between 1948 and 1961 were re-examined and their histological diagnoses either confirmed or adjusted. In addition, all those cases where a diagnosis of malignant, pre-malignant, or possibly malignant melanoma was made were followed up, by reference to the hospital notes if the patient had attended Moorfields Eye Hospital, and by writing to the referring surgeon or pathologist if the patient had attended another hospital. The purpose of this study is threefold. First, to classify naevi and malignant melanomata of the conjunctiva both with regard to accepted nomenclature and as a result of examining 400 such neoplasms histologically. Second, to ascertain the degree of malignancy of those tumours that are frankly malignant and of those that show changes suggestive of malignancy. Third, to compare the histological appearances of naevi and malignant melanomata of the conjunctiva with those of the skin.