Abnormalities of leukocyte chemotaxis in patients with various forms of periodontitis.
Abnormalities of leukocyte chemotaxis in patients with various forms of periodontitis.
复制标题
各种形式的牙周炎患者白细胞趋化性异常。
DOI：
10.1111/j.1600-0765.1985.tb00839.x
复制
发表时间：
1985
影响因子：
3.5
通讯作者：
Bradford,C
中科院分区：
文献类型：
--
作者：
Altman,LC;Page,RC;Vandesteen,GE;Dixon,LI;Bradford,C
先前的研究表明，大多数青少年牙周炎患者抑制多形核白细胞（PMN）趋化性。然而，在其他形式的早发性牙周炎中，对PMN迁移的研究仅在有限程度上或根本没有研究，单核细胞（MN）趋化性在任何形式的牙周炎患者中尚未得到广泛研究。因此，我们对7例青春期前患者、37例青少年患者和35例快速进展性牙周炎患者进行了PMN和MN趋化性研究。另外，对8例成人牙周炎患者进行了PMN趋化性研究。青春期前组PMN趋化性异常5例，MN趋化性降低5例，血清趋化活性降低1例。本组所有患者至少有一种形式的白细胞趋化性异常。在青少年牙周炎组，17例患者有异常的PMN反应，其中16例降低，1例增强。其中4例患者MN趋化性降低，2例患者MN趋化性升高。5例患者血清趋化活性降低，1例显示血清趋化抑制剂。总的来说，65%的青少年患者有某种形式的异常。在快速进展组中，15例PMN趋化性异常，7例MN趋化性异常，4例血清趋化活性降低，8例血清趋化抑制剂。成人牙周炎患者的pmn及血清未见异常。总体而言，66%的早发患者表现出某种形式的细胞或血清相关白细胞趋化异常。因此，白细胞趋化性异常存在于所有青春期前牙周炎患者和大多数青少年和快速进展的疾病患者中，而8例成人牙周炎患者未发现异常。
Prior studies have documented that a majority of patients with juvenile periodontitis have suppressed polymorphonuclear leukocyte (PMN) chemotaxis. However, in other forms of earlyonset periodontitis, PMN migration has been studied only to a limited extent or not at all, and monocyte (MN) chemotaxis has not been extensively studied in patients with any of the forms of periodontitis. Accordingly, PMN and MN chemotaxis was studied in 7 patients with prepubertal, 37 with juvenile, and 35 with rapidly progressive periodontitis. In addition, PMN chemotaxis was studied in 8 patients with adult periodontitis. In the prepubertal group, 5 patients had abnormal PMN chemotaxis, 5 had depressed MN chemotaxis, and one had reduced serum chemotactic activity. All patients in this group had at least one form of leukocyte chemotaxis abnormality. In the juvenile periodontitis group, 17 patients had abnormal PMN responses, 16 of these were depressed while 1 was enhanced. MN chemotaxis was depressed in 4 of these patients and elevated in 2. Five patients had reduced serum chemotactic activity and one manifested a serum chemotactic inhibitor. In total, 65% of juvenile patients had some form of abnormality. In the rapidly progressive group, 15 had abnormal PMN chemotaxis, 7 had aberrant MN chemotaxis, 4 had reduced serum chemotactic activity, and 8 had a serum inhibitor of chemotaxis. No abnormalities were found in the PMNs or sera of patients with adult periodontitis. Overall, 66% of the early‐onset patients manifested some form of cell or serum‐related leukocyte chemotactic abnormality. Thus, abnormalities of leukocyte chemotaxis were present in all patients with prepubertal periodontitis and in a majority of those with juvenile and rapidly progressive disease, while no abnormalities were found in 8 patients with adult periodontitis.