Cladosins A-E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum
Cladosins A-E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum
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Cladosins A-E，来自深海衍生真菌 Cladosporium sphaerospermum 的杂化聚酮化合物
DOI：
10.1021/np400833x
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发表时间：
2014-02-01
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Wu, Guangwei;Sun, Xinhua;Li, Dehai
从深海来源的真菌球孢枝孢菌2005-01-E3中分离出五种新的真菌杂合聚酮化合物，枝孢素A-D（1-4），它们含有一种新的线性6（3）-烯氨基-8，10-二羟基-四酮化合物（1和2）或6-烯氨基-7（8）-烯-10-醇（3和4）部分，以及生物遗传学相关的枝孢素E（5）。它们的结构（1-5）通过光谱数据、化学转化以及用于立体化学归属的Mosher和Marveland方法的组合来阐明。一个合理的生物遗传途径1-5的建议。克拉多辛C（3）具有温和的抗甲型H1N1流感病毒活性。
Five new fungal hybrid polyketides, cladosins A-D (1-4), that contain a novel linear 6(3)-enamino-8,10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7(8)-en-10-ol (3 and 4) moiety, as well as the biogenetically related cladosin E (5), were isolated from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3. Their structures (1-5) were elucidated through a combination of spectroscopic data, chemical conversion, and both Mosher's and Marfey's methods for stereochemical assignment. A plausible biogenetic pathway to 1-5 is proposed. Cladosin C (3) possesses mild anti-influenza A H1N1 virus activity.