Comparison of Static and Dynamic Cardiac Perfusion Thallium-201 SPECT.
Comparison of Static and Dynamic Cardiac Perfusion Thallium-201 SPECT.
复制标题
静态和动态心脏灌注铊-201 SPECT 的比较。
DOI：
10.1109/23.940162
复制
发表时间：
2001
影响因子：
1.8
通讯作者：
Gullberg,GrantT
中科院分区：
文献类型：
--
作者：
Khare,HarshaliS;Dibella,EdwardVR;Kadrmas,DanJ;Christian,PaulE;Gullberg,GrantT
心脏SPECT通常在临床上使用静态成像协议进行，并根据心肌区域的相对强度视觉评估灌注缺陷。然而，动态成像有可能提供流量的定量测量，可能提高诊断。本研究的目的是比较动态和静态铊SPECT成像作为心肌灌注测量的信息含量。研究在四只犬中进行，每只犬的左冠状动脉前降支闭塞。在静止和腺苷应激下进行动态SPECT成像，并对数据子集进行汇总，以提供相同生理条件下相应的静态数据集。微球衍生的流量测量被用作金标准。动态数据拟合到一个双室模型，以提供水洗率参数的区域估计。还计算了每个犬类研究的闭塞与正常比率。结果显示与微球的冲洗和静态缩放图像强度具有可比的相关性。动态数据提供了更高的缺陷对比，比静态闭塞正常比更准确。对2例患者进行了初步研究，并对静态和动态数据进行了比较。这些结果表明，与静态成像相比，动态铊成像可以为心肌灌注SPECT研究提供更好的诊断信息。
Cardiac SPECT is typically performed clinically with static imaging protocols and visually assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic imaging, however, has the potential to provide quantitative measures of flow, possibly improving diagnosis. The objective of this study was to compare the information content of dynamic and static thallium SPECT imaging as measures of myocardial perfusion. Studies were performed in four canines, each with an occlusion placed on the left anterior descending coronary artery. Dynamic SPECT imaging was performed at rest and under adenosine stress, and subsets of the data were summed to provide corresponding static datasets for identical physiologic conditions. Microsphere-derived flow measurements were used as the gold standard. The dynamic data were fit to a two-compartment model to provide regional estimates of wash-in rate parameters. Occluded-to-normal ratios were also calculated for each canine study. The results show comparable correlations with microspheres for both wash-in and static scaled image intensities. The dynamic data provided higher defect contrasts, which were more accurate than the static occluded to normal ratios. Preliminary studies were also performed in two patients and the static and dynamic data compared. These results show that dynamic thallium imaging may provide improved diagnostic information compared to static imaging for myocardial perfusion SPECT studies.