Morris water maze test for learning and memory deficits in Alzheimer's disease model mice.
Morris water maze test for learning and memory deficits in Alzheimer's disease model mice.
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DOI：
10.3791/2920
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发表时间：
2011-07-20
期刊：
影响因子：
--
通讯作者：
Song, Weihong
中科院分区：
文献类型：
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作者：
Bromley-Brits, Kelley;Deng, Yu;Song, Weihong
莫里斯水迷宫（Morris Water Maze， MWM）由神经科学家Richard G. Morris于1981年首次建立，旨在测试海马体依赖性学习，包括空间记忆和长期空间记忆的获得。MWM是一个相对简单的过程，通常由6天的试验组成，主要优点是空间（隐藏平台）和非空间（可见平台）条件的区分。此外，MWM测试环境减少了气味痕迹的干扰。这使得这项任务被广泛应用于空间学习和记忆的神经生物学和神经药理学研究中。MWM在验证神经认知障碍（如阿尔茨海默病）的啮齿动物模型中起着重要作用。在本协议中，我们讨论了常用的MWM用于阿尔茨海默病转基因模型小鼠的学习记忆测试和数据分析的典型程序。
The Morris Water Maze (MWM) was first established by neuroscientist Richard G. Morris in 1981 in order to test hippocampal-dependent learning, including acquisition of spatial memory and long-term spatial memory. The MWM is a relatively simple procedure typically consisting of six day trials, the main advantage being the differentiation between the spatial (hidden-platform) and non-spatial (visible platform) conditions. In addition, the MWM testing environment reduces odor trail interference. This has led the task to be used extensively in the study of the neurobiology and neuropharmacology of spatial learning and memory. The MWM plays an important role in the validation of rodent models for neurocognitive disorders such as Alzheimer's Disease. In this protocol we discussed the typical procedure of MWM for testing learning and memory and data analysis commonly used in Alzheimer's disease transgenic model mice.