Poly hydroxyalkanoates (PHA): Role in bone scaffolds.
Poly hydroxyalkanoates (PHA): Role in bone scaffolds.
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DOI：
10.1016/j.jobcr.2019.10.004
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发表时间：
2020-01-01
影响因子：
--
通讯作者：
Mehrotra, Divya
中科院分区：
文献类型：
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作者：
Dwivedi, Ruby;Pandey, Rahul;Mehrotra, Divya
聚羟基脂肪酸酯（PHA）是原核生物的大分子，在细胞质中以颗粒形式积累。由于其合适的机械性能、生物相容性、降解时间、共混、表面改性和形成共聚物的能力，其被广泛用于医疗器械和骨组织工程中的支架。本文简要介绍了各种PHA及其共聚物的生产、提取来源、理化特性、力学性能、降解速率及应用，重点介绍了其作为骨组织工程支架材料的作用。
Polyhydroxyalkanoates (PHA) are prokaryotic macromolecules accumulated within the cytoplasm as granules. Due to their suitable mechanical properties, biocompatibility, degradation time, ability to be blended, surface modified, and form copolymers, it is widely used in medical devices and as scaffolds in bone tissue engineering. This review describes in brief the production and extraction sources, physico-chemical characteristic, mechanical properties, degradation rate and applications of various PHAs and its copolymers with special emphasis to its role as scaffolds in bone tissue engineering.