Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a π-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a π-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
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DOI：
10.1039/b308793j
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发表时间：
2003-01-01
影响因子：
3.2
通讯作者：
Hollowood, CJ
中科院分区：
文献类型：
--
作者：
Ley, SV;Cleator, E;Hollowood, CJ
报道了种子萌发自抑制剂（-）-粘孢酮的合成。在产物中嵌入的1，7-二醇基序通过铁羰基栓系控制的Mukaiyama羟醛缩合反应构建。合成中的关键步骤是通过用萘锂处理乙酰氧基络合物6来还原除去配位铁物种。
The synthesis of the germination self-inhibitor (-)-Gloeosporone is reported. The embedded 1,7-diol motif in the product is constructed by an ironcarbonyl tether controlled Mukaiyama aldol reaction. The key step in the synthesis is the reductive removal of the ligating iron species by treatment of an acetoxycomplex 6 with lithium naphthalenide.