Long-term reorganization of human motor cortex driven by short-term sensory stimulation
Long-term reorganization of human motor cortex driven by short-term sensory stimulation
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DOI：
10.1038/264
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发表时间：
1998-05-01
影响因子：
25
通讯作者：
Thompson, DG
中科院分区：
文献类型：
--
作者：
Hamdy, S;Rothwell, JC;Thompson, DG
感觉输入的去除可以引起皮质运动表征的变化，当感觉恢复时，这种变化会逆转。在这里，我们要问的是，对感觉输入的操纵是否能诱导人类运动皮层的长期重组，这种重组的持续时间超过最初的条件反射。我们报告说，至少30分钟后，咽部刺激，运动皮层的兴奋性和区域的代表性增加，而食道代表性下降，脑干介导的反射的兴奋性没有平行的变化。因此，增加的感觉输入可以驱动大脑皮层运动区的长期跨系统变化，这表明感觉刺激可能会恢复吞咽困难，这是脑损伤的常见后果。
Removal of sensory input can induce changes in cortical motor representation that reverse when sensation is restored. Here we ask whether manipulation of sensory input can induce long-term reorganization in human motor cortex that outlasts the initial conditioning. We report that for at least 30 minutes after pharyngeal stimulation, motor cortex excitability and area of representation for the pharynx increased, while esophagus representation decreased, without parallel changes in the excitability of brainstem-mediated reflexes. Therefore increased sensory input can drive long-term cross-system changes in motor areas of the cerebral cortex, which suggests that sensory stimulation might rehabilitate dysphagia, a frequent consequence of cerebral injury.