Herpes simplex virus glycoprotein immunotherapy of recurrent genital herpes: factors influencing efficacy.
Herpes simplex virus glycoprotein immunotherapy of recurrent genital herpes: factors influencing efficacy.
复制标题
单纯疱疹病毒糖蛋白免疫治疗复发性生殖器疱疹：影响疗效的因素。
DOI：
10.1016/0166-3542(89)90005-3
复制
发表时间：
1989
影响因子：
7.6
通讯作者：
Myers,MG
中科院分区：
文献类型：
--
作者：
Stanberry,LR;Harrison,CJ;Bernstein,DI;Burke,RL;Shukla,R;Ott,G;Myers,MG
用重组单纯疱疹病毒1型（HSV-1）糖蛋白B（gB）和D（gD）作为免疫抑制剂治疗豚鼠复发性生殖器疱疹。阴道内接种HSV-2后8 ~ 21天接种gBgD疫苗可显著提高抗HSV抗体滴度（P<0.005），同时显著降低疱疹复发率（P<0.05）。gBgD免疫治疗的有效性受佐剂联合给药、佐剂类型以及给药时间和途径的影响。这些数据表明，通过给予免疫原性病毒蛋白，可以有利地改变已建立潜伏感染的动物中复发的单纯疱疹病毒疾病。
Recombinant herpes simplex virus type 1 (HSV-1) glycoproteins B (gB) and D (gD) were used as immunotherapeutic agents for the treatment of recurrent genital herpes in guinea pigs. Administration of a gBgD vaccine eight to 21 days after intravaginal HSV-2 inoculation significantly increased the titer of anti-HSV antibodies (P<0.005) while significanlty reducing the frequency of subsequent herpetic recurrences (P<0.05). The effectiveness of gBgD immunotherapy was influenced by both the co-administration of adjuvant, the type of adjuvant, and by the timing and route of administration. These data demonstrate that recurrent HSV disease in animals with established latent infection may be favorably altered by the administration of immunogenic viral proteins.