Influence of internal fixation systems on radiation therapy for spinal tumor.
Influence of internal fixation systems on radiation therapy for spinal tumor.
复制标题
内固定系统对脊柱肿瘤放射治疗的影响
DOI：
10.1120/jacmp.v16i4.5450
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发表时间：
2015-07-08
影响因子：
2.1
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Li J;Yan L;Wang J;Cai L;Hu D
本研究旨在探讨内固定系统对脊柱肿瘤放射治疗的影响，为调整脊柱肿瘤患者的放射剂量及内固定提供理论依据。在脊柱肿瘤切除后常用内固定方法的基础上，以新鲜家猪腰椎和钛合金为内固定系统，构建不同的脊柱内固定模型。研究不同内固定方式在相同的照射条件下(6 MV和600mGY)、不同固定模式下椎体和部分脊髓的辐射剂量变化，并与按治疗计划系统(TPS)进行的照射进行比较。结果表明，脊柱内固定材料对脊柱肿瘤吸收的辐射剂量有很大影响。在相同的照射条件下，前路内固定材料或前后联合入路对椎体前缘照射剂量的影响最大。无论采用何种内固定方法，椎体前缘的辐射剂量与其他部位的辐射剂量有显著差异。值得注意的是，后路内固定材料对椎管前壁的影响最大。对于大多数接受金属种植体固定的骨转移患者，应考虑X射线的衰减和散射。然后，应对改进的TPS进行进一步评估，以最大限度地减少不适当辐射剂量的潜在有害影响。PAC编号：87.55.D-
In this study, the influence of internal fixation systems on radiation therapy for spinal tumor was investigated in order to derive a theoretical basis for adjustment of radiation dose for patients with spinal tumor and internal fixation. Based on a common method of internal fixation after resection of spinal tumor, different models of spinal internal fixation were constructed using the lumbar vertebra of fresh domestic pigs and titanium alloy as the internal fixation system. Variations in radiation dose in the vertebral body and partial spinal cord in different types of internal fixation were studied under the same radiation condition (6 MV and 600 mGy) in different fixation models and compared with those irradiated based on the treatment planning system (TPS). Our results showed that spinal internal fixation materials have great impact on the radiation dose absorbed by spinal tumors. Under the same radiation condition, the influence of anterior internal fixation material or combined anterior and posterior approach on radiation dose at the anterior border of the vertebral body was the greatest. Regardless of the kinds of internal fixation method employed, radiation dose at the anterior border of the vertebral body was significantly different from that at other positions. Notably, the influence of posterior internal fixation material on the anterior wall of the vertebral canal was the greatest. X‐ray attenuation and scattering should be taken into consideration for most patients with bone metastasis that receive fixation of metal implants. Further evaluation should then be conducted with modified TPS in order to minimize the potentially harmful effects of inappropriate radiation dose. PACS number: 87.55.D‐
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影响因子：
3.8
作者：
du Plessis, FCP;Willemse, CA;Goedhals, L
通讯作者：
Goedhals, L
影响因子：
3.8
作者：
Jia, Yingcui;Beltran, Chris;Merchant, Thomas E.
通讯作者：
Merchant, Thomas E.
直肠癌术前放疗或化放疗与手术之间的最佳时间间隔？
影响因子：
4.7
作者：
Glimelius B
通讯作者：
Glimelius B
影响因子：
3.8
作者：
Reft, C;Alecu, R;Van Dyk, J
通讯作者：
Van Dyk, J
影响因子：
2.1
作者：
Niedzielski J;Bluett JB;Williamson RT;Liao Z;Gomez DR;Court LE
通讯作者：
Court LE