Collagen-targeted molecular imaging in diffuse liver diseases.
Collagen-targeted molecular imaging in diffuse liver diseases.
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DOI：
10.1007/s00261-020-02677-2
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Caravan P
中科院分区：
文献类型：
--
作者：
Zhou IY;Tanabe KK;Fuchs BC;Caravan P
Liver fibrosis is a common pathway shared by all progressive chronic liver disease (CLD) regardless of the underlying etiologies. With liver biopsy being the gold standard in assessing fibrosis degree, there is a large unmet clinical need to develop noninvasive imaging tools that can directly and repeatedly quantify fibrosis throughout the liver for a more accurate assessment of disease burden, progression, and treatment response. Type I collagen is a particularly attractive target for molecular imaging as its excessive deposition is specific to fibrosis, and it is present in concentrations suitable for many imaging modalities. Novel molecular MRI contrast agents designed to bind with collagen provide direct quantification of collagen deposition, which have been validated across animal species and liver injury models. Collagen targeted molecular imaging probes hold great promise not only as a tool for initial staging and surveillance of fibrosis progression, but also as a marker of fibrosis regression in drug trials.
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影响因子：
29.4
作者：
Huwart, Laurent;Sempoux, Christine;Van Beers, Bernard E.
通讯作者：
Van Beers, Bernard E.
DOI：
10.1111/j.1440-1746.2011.07006.x
发表时间：
2012-03-01
影响因子：
4.1
作者：
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通讯作者：
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影响因子：
9.3
作者：
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通讯作者：
Caravan, Peter
影响因子：
8
作者：
Chen, Howard H.;Waghorn, Philip A.;Caravan, Peter
通讯作者：
Caravan, Peter
I型胶原蛋白靶向PET探针，用于临床前模型中的肺纤维化检测和分期。
影响因子：
17.1
作者：
Désogère P;Tapias LF;Hariri LP;Rotile NJ;Rietz TA;Probst CK;Blasi F;Day H;Mino-Kenudson M;Weinreb P;Violette SM;Fuchs BC;Tager AM;Lanuti M;Caravan P
通讯作者：
Caravan P