Compensatory brain activity during encoding among older adults with better recognition memory for face-name pairs: an integrative functional, structural, and perfusion imaging study.
Compensatory brain activity during encoding among older adults with better recognition memory for face-name pairs: an integrative functional, structural, and perfusion imaging study.
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DOI：
10.1017/s1355617712000197
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发表时间：
2012-05
影响因子：
2.6
通讯作者：
Eyler, Lisa T.
中科院分区：
文献类型：
--
作者：
Bangen, Katherine J.;Kaup, Allison R.;Mirzakhanian, Heline;Wierenga, Christina E.;Jeste, Dilip V.;Eyler, Lisa T.
许多神经影像学研究解释了常见的研究结果与年龄相关的额叶反应和/或增加双边激活提示代偿性神经募集。然而，通常不清楚差异是否是由于补偿或反映其他认知或生理过程。本研究的目的是确定是否有代偿性年龄相关的变化，在大脑系统支持成功的联想编码，同时考虑到潜在的混杂因素，包括年龄相关的差异，任务性能，萎缩，和静息灌注。在10名老年人和9名年轻人中，使用功能性磁共振成像测量了面孔-名称对编码过程中的大脑反应，并与记忆表现相关。在成功的编码，老年人表现出增加额叶和减少枕叶活动，以及更大的双边参与相对于年轻人。在控制年龄相关的皮质萎缩和灌注不足后，结果仍然显著。在老年人中，更大的反应与更好的记忆表现有关。认知老化可能涉及补偿机制的招募，以提高性能或防止损伤。结果扩展了以前的研究结果表明，年龄相关的激活变化不能归因于常见的发现较差的任务性能，减少静息灌注，或老年人皮质萎缩。
Many neuroimaging studies interpret the commonly reported findings of age-related increases in frontal response and/or increased bilateral activation as suggestive of compensatory neural recruitment. However, it is often unclear whether differences are due to compensation or reflective of other cognitive or physiological processes. This study aimed to determine whether there are compensatory age-related changes in brain systems supporting successful associative encoding while taking into account potentially confounding factors including age-related differences in task performance, atrophy, and resting perfusion. Brain response during encoding of face-name pairs was measured using functional magnetic resonance imaging in 10 older and nine young adults and was correlated with memory performance. During successful encoding, older adults demonstrated increased frontal and decreased occipital activity as well as greater bilateral involvement relative to the young. Findings remained significant after controlling for age-related cortical atrophy and hypoperfusion. Among the older adults, greater response was associated with better memory performance. Cognitive aging may involve recruitment of compensatory mechanisms to improve performance or prevent impairment. Results extend previous findings by suggesting that age-related alterations in activation cannot be attributed to the commonly observed findings of poorer task performance, reduced resting perfusion, or cortical atrophy among older adults.