Planning deficits in HIV-associated neurocognitive disorders: Component processes, cognitive correlates, and implications for everyday functioning
Planning deficits in HIV-associated neurocognitive disorders: Component processes, cognitive correlates, and implications for everyday functioning
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DOI：
10.1080/13803395.2012.692772
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发表时间：
2012-01-01
影响因子：
2.2
通讯作者：
Woods, Steven Paul
中科院分区：
文献类型：
--
作者：
Cattie, Jordan E.;Doyle, Katie;Woods, Steven Paul
执行功能障碍仍然是HIV相关神经认知障碍（HAND）患者中最常见的认知领域受损。然而，很少有人知道具体的认知架构或日常功能的影响，规划，这是一个方面的执行功能，涉及识别，组织和完成顺序行为，以实现一个目标。目前的研究使用伦敦塔（DX）对53名HAND患者、109名无HAND的HIV感染者和82名血清阴性参与者进行了研究。HAND+组在正确移动次数、总移动次数、执行时间、违反时间和违反规则方面的表现明显低于没有HAND的HIV感染者。在HIV+组作为一个整体，更大的总移动分数和违反规则与执行功能障碍最密切相关。临床相关性，升高的总动作和违反规则的自我报告的工具性日常生活活动和失业状态下降的艾滋病毒的显着，独立的预测因子。这些结果表明，计划的准确性，效率和规则约束控制受损的手，并可能有意义地影响更复杂的认知方面的日常生活。
Executive dysfunction remains among the most prevalent cognitive domains impaired in persons with HIV-associated neurocognitive disorders (HAND). However, little is known specifically about the cognitive architecture or everyday functioning implications of planning, which is an aspect of executive functions involving the identification, organization, and completion of sequential behaviours toward the accomplishment of a goal. The current study examined these issues using the Tower of London(DX) in 53 individuals with HAND, 109 HIV-infected persons without HAND, and 82 seronegative participants. The HAND+ group performed significantly more poorly than HIV-infected individuals without HAND on number of correct moves, total moves, execution time, time violations, and rule violations. Within the HIV+ group as a whole, greater total move scores and rule violations were most strongly associated with executive dysfunction. Of clinical relevance, elevated total moves and rule violations were significant, independent predictors of self-reported declines in instrumental activities of daily living and unemployment status in HIV. These results suggest that planning accuracy, efficiency, and rule-bound control are impaired in HAND and may meaningfully affect more cognitively complex aspects of everyday living.