Subclinical thyroid disease in patients with Parkinson's disease
Subclinical thyroid disease in patients with Parkinson's disease
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DOI：
10.1016/s0167-4943(01)00196-0
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发表时间：
2001-11-01
影响因子：
4
通讯作者：
Shvartzman, P
中科院分区：
文献类型：
--
作者：
Tandeter, H;Levy, A;Shvartzman, P
本研究的目的是确定甲状腺功能减退症在帕金森病患者中是否比没有帕金森病的对照组更常见，正如过去所建议的那样。我们对一年内所有入住老年病房的患者进行了回顾性档案审查。将 92 名帕金森患者的促甲状腺激素 (TSH) 和甲状腺素 (T4) 浓度与来自同一病房的 225 名随机选择的对照进行比较。甲状腺功能减退症并没有像之前所说的那样在帕金森病患者中更为常见。顺便说一句，我们发现该组中甲状腺实验室检查异常的发生率出人意料地增加。两个亚组之间存在统计学上的显着差异：(1) 与对照组相比，患有帕金森病的男性更容易出现甲状腺实验室检查异常； (2) 帕金森病患者中“亚临床”甲状腺功能亢进症比对照组更为普遍。需要在非住院患者中进行该领域的进一步研究。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
The objective of this study was to determine whether hypothyroidism is more common in Parkinson patients than in a control group without Parkinson, as suggested in the past. We performed a retrospective file review of all admissions to the geriatric ward during a 1-year period. Concentrations of thyroid stimulating hormone (TSH) and thyroxine (T4) from 92 Parkinson patients were compared with those of 225 randomly selected controls from the same ward. Hypothyroidism was not found to be more common in patients with Parkinson disease as previously suggested. Incidentally, we found an unexpected increase in the prevalence of abnormal thyroid laboratory tests in this group. Statistically significant differences were found in two subgroups, (1) men with Parkinson were more likely to have abnormal thyroid laboratory tests as compared with controls; and (2) 'subclinical' hyperthyroidism was found to be more prevalent in Parkinson patients than in controls. Further research in this field is warranted in non-hospitalized patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.