Hippocampal Pathology in Schizophrenia
Hippocampal Pathology in Schizophrenia
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DOI：
10.1007/7854_2010_43
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Konradi, Christine
中科院分区：
文献类型：
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作者：
Heckers, Stephan;Konradi, Christine
精神分裂症患者的海马体异常。海马体积变小是最一致的发现，并且在疾病的早期阶段就已经存在。潜在的细胞基质是海马中间神经元的微妙但功能显著的减少。神经影像学研究揭示了一种模式，即海马活动在基线时增加，而在记忆任务的执行过程中招募减少。啮齿类动物的海马损伤模型复制了精神分裂症的一些药理学、解剖学和行为表型。总之，这种模式的研究结果表明，海马锥体细胞的抑制解除和异常的皮质-海马相互作用的精神分裂症。
The hippocampus is abnormal in schizophrenia. Smaller hippocampal volume is the most consistent finding and is present already in the early stages of the illness. The underlying cellular substrate is a subtle, yet functionally significant reduction of hippocampal interneurons. Neuroimaging studies have revealed a pattern of increased hippocampal activity at baseline and decreased recruitment during the performance of memory tasks. Hippocampal lesion models in rodents have replicated some of the pharmacological, anatomical and behavioral phenotype of schizophrenia. Taken together, this pattern of findings points to a disinhibition of hippocampal pyramidal cells and abnormal cortico-hippocampal interactions in schizophrenia.