Toxicity and health effects of selected organotin compounds: a review.
Toxicity and health effects of selected organotin compounds: a review.
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选定有机素化合物的毒性和健康作用：评论。
DOI：
10.1289/ehp.761451
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发表时间：
1976-04
影响因子：
10.4
通讯作者：
Kimbrough RD
中科院分区：
文献类型：
--
作者：
Kimbrough RD
综述了几种锡化合物的毒性。多年来，人们发现有机和无机锡化合物有多种用途，如杀菌剂、塑料稳定剂、杀虫剂和杀螨剂；它们也被建议作为昆虫化学灭菌剂和其他工业用途。这些产品中有许多在混合到饮食中是不美味的，被建议作为啮齿动物的驱虫剂。以粉尘或烟雾形式吸入锡可使接触锡的工人患上良性尘肺病。有机锡化合物可分为烷基锡化合物和芳基锡化合物。三甲基和三乙基锡化合物很容易被胃肠道吸收，是这类化合物中毒性最大的。三乙基锡特别产生中枢神经系统白质的海绵状状态。大多数其他烷基锡和芳基锡化合物从胃肠道吸收不良，口服比父母给药毒性小。目前只有一种化合物，三环己基氢氧化锡，被环境保护局注册为杀虫剂。本品对家兔皮肤有刺激作用。应进行研究以确定它是否会引起人类接触性皮炎。
The toxicity of selected tin compounds is reviewed. Over the years, a variety of uses has been found for organic and inorganic tin compounds, as fungicides, as stablizers in plastics, moluscicides, and miticides; they have also been suggested as insect chemosterilants and for other industrial uses. Many of these products are unpalatable when mixed into diets and have been suggested as rodent repellents. Inhaling tin as dust or fumes may cause a benign pneumoconiosis in exposed workers. The organotin compounds can be divided into alkyltin and aryltin compounds. The trimethyl and triethyltin compounds are well absorbed from the gastrointestinal tract and are the most toxic in this group. Triethyltin particularly produces status spongiosus of the white matter of the central nervous system. Most of the other alkyl and aryl tin compounds are poorly absorbed from the gastrointestinal tract, and are less toxic when given orally than when given parentally. Only one compound, tricyclohexyltin hydroxide, is now registered by the Environmental Protection Agency as a miticide. This product produces skin irritation in rabbits. Studies should be conducted to determine whether it causes contact dermatitis in humans.