Expression of vascular endothelial growth factor in basal cell carcinoma and cutaneous squamous cell carcinoma of the head and neck
Expression of vascular endothelial growth factor in basal cell carcinoma and cutaneous squamous cell carcinoma of the head and neck
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DOI：
10.1034/j.1600-0560.2002.291003.x
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发表时间：
2002-11-01
影响因子：
1.7
通讯作者：
Cronin, A
中科院分区：
文献类型：
--
作者：
Bowden, J;Brennan, PA;Cronin, A
背景：基底细胞癌（BCC）和鳞状细胞癌（SCC）都可以起源于任何皮肤上皮表面。 BCC 生长缓慢且很少转移，而 SCC 通常更具侵袭性。血管生成过程很可能在决定生长速率和扩散倾向方面发挥关键作用。血管生成是一个需要多种因素参与的复杂过程，其中参与该过程的关键蛋白质组是血管内皮生长因子（VEGF）。方法：在44例基底细胞癌和41例头颈部皮肤鳞状细胞癌中检测VEGF的免疫组织化学表达。结果：VEGF在邻近皮肤和肿瘤的血管内皮细胞中表达，并且在 表皮的基底角质形成细胞层。在 BCC 中，24/44 例肿瘤上皮细胞表达 VEGF，主要在浸润性肿瘤前沿，其表达显着高于邻近皮肤 (p = 0.038)。在 32/41 例鳞状细胞癌中发现更广泛的 VEGF 表达，并且与肿瘤分化程度显着相关 (p < 0.001)。结论：基底细胞癌和鳞状细胞癌中的 VEGF 表达模式可能有助于解释这些肿瘤通常出现的不同行为。
Background: Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) can both arise from any cutaneous epithelial surface. BCC are slow growing and rarely metastasise, whereas SCC are usually more aggressive. It is likely that the angiogenic process plays a key role in determining rate of growth and propensity for dissemination. Angiogenesis is a complex process requiring many factors and a pivotal group of proteins involved in this process is vascular endothelial growth factor (VEGF).Methods: Immunohistochemical expression of VEGF was assessed in 44 cases of BCC and 41 cases of cutaneous SCC from the head and neck region.Results: VEGF was expressed by blood vessel endothelial cells in both adjacent skin and tumour, and in the basal keratinocyte layer of epidermis. In BCC, VEGF was expressed by tumour epithelial cells, predominantly at the invasive tumour front, in 24/44 cases and its expression was significantly greater than in adjacent skin (p = 0.038). More widespread VEGF expression was found in 32/41 cases of SCC, and it was significantly associated with the degree of tumour differentiation (p < 0.001).Conclusions: The patterns of VEGF expression in BCC and SCC may help to explain the different behaviour that is usually seen with these tumours.