Limited lipid-lowering effects of regular consumption of whole soybean foods
Limited lipid-lowering effects of regular consumption of whole soybean foods
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DOI：
10.1159/000075592
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发表时间：
2004-01-01
影响因子：
3.9
通讯作者：
Howe, PRC
中科院分区：
文献类型：
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作者：
Meyer, BJ;Larkin, TA;Howe, PRC
目的：检查含有全大豆提取物的食品对心血管健康的益处。方法：该研究设计是一项随机、安慰剂对照的交叉试验，每次食用豆奶和酸奶（治疗）或同等乳制品（对照）5 周。从社区招募了 26 名轻度高胆固醇血症和/或高血压志愿者作为研究志愿者，其中 23 人完成了研究。主要结果指标包括临床血压和动态血压、动脉顺应性、空腹血液中的脂质、脂肪酸和异黄酮以及24小时尿异黄酮排泄量。最初和每 5 周后评估营养摄入量。使用多元回归分析来确定统计模型中的预测变量；通过重复测量方差分析来测试顺序效应。 Lp(a) 的变化通过 Wilcoxon 符号秩检验确定；通过 t 检验评估治疗组和对照组之间的其他差异。结果：补充全豆后，血浆和尿液中的异黄酮显着增加，但大豆和乳制品饮食之间的血浆脂质、血压或动脉顺应性没有总体差异。然而，在 8 名雌马酚阳性受试者中（在血浆或尿液中检测到雌马酚），回顾性分析显示，大豆饮食显着降低了总胆固醇 (8.5%)、LDL 胆固醇 (10%)、LDL: HDL 比率 (13.5%)、血浆甘油三酯 (21%) 和脂蛋白 (a) (11%)。这些减少与多不饱和脂肪和其他常量营养素摄入量的变化无关。结论：尽管血液和尿液中的异黄酮水平大幅增加，但经常食用全脂豆浆和酸奶产品对高危受试者的血脂、血压或动脉顺应性没有影响。回顾性分析表明，血脂的改善可能仅限于雌马酚阳性受试者。版权所有 (C) 2004 S. Karger AG，巴塞尔。
Aim: To examine cardiovascular health benefits of foods containing a whole soybean extract. Methods: The study design was a randomized, placebo-controlled crossover trial of consuming soy-based milk and yoghurt (treatment) or equivalent dairy products (control) for 5 weeks each. Twenty-six mildly hypercholesterolaemic and/or hypertensive volunteers were recruited from the community as study volunteers, of which 23 completed. Main outcome measures included clinic and ambulatory blood pressure, arterial compliance, lipids, fatty acids and isoflavones in fasted blood and 24-hour urinary isoflavone excretion. Nutrient intakes were assessed initially and after each 5-week period. Multiple regression analyses were used to determine predictor variables in statistical models; order effects were tested by repeated measures ANOVA. Changes in Lp(a) were determined by Wilcoxon signed ranks tests; other differences between treatment and control were assessed by t tests. Results: Plasma and urinary isoflavones were markedly increased by whole soy supplementation but there were no overall differences in plasma lipids, blood pressure or arterial compliance between the soy and dairy diets. However, in 8 equol-positive subjects (equol detected in either plasma or urine), retrospective analysis revealed significant reductions in total cholesterol (8.5%), LDL cholesterol (10%), LDL: HDL ratio (13.5%), plasma triglycerides (21%) and lipoprotein(a) (11%) with the soy diet. These reductions were independent of changes in polyunsaturated fat and other macronutrient intakes. Conclusions: Regular consumption of whole soybean milk and yogurt products had no effect on plasma lipids, blood pressure or arterial compliance in at-risk subjects, despite substantially increasing isoflavone levels in blood and urine. Retrospective analysis suggests that improvement of plasma lipids may have been limited to equol-positive subjects. Copyright (C) 2004 S. Karger AG, Basel.