MANAGEMENT OF LATENT TUBERCULOSIS INFECTION IN CHILD CONTACTS OF MULTIDRUG-RESISTANT TUBERCULOSIS
MANAGEMENT OF LATENT TUBERCULOSIS INFECTION IN CHILD CONTACTS OF MULTIDRUG-RESISTANT TUBERCULOSIS
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DOI：
10.1097/inf.0000000000000260
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发表时间：
2014-06-01
影响因子：
3.6
通讯作者：
Singh, Jasjit
中科院分区：
文献类型：
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作者：
Adler-Shohet, Felice C.;Low, Julie;Singh, Jasjit
在接触患有耐多药肺结核的老师后，31名儿童出现了潜伏感染。二十六人接受左氧氟沙星和吡嗪酰胺治疗。十二人因不良反应而需要改变治疗方法。最常见的不良反应包括腹痛、关节痛/肌痛和转氨酶升高。所有儿童均报告至少 1 种不良反应。十五名儿童完成了治疗。所有不良反应都是短暂的。
After exposure to a teacher with multidrug-resistant pulmonary tuberculosis, 31 children developed latent infection. Twenty-six were treated with levofloxacin and pyrazinamide. Twelve required a change in therapy secondary to adverse effects. The most common adverse effects included abdominal pain, arthralgias/myalgias and elevated transaminases. All children reported at least 1 adverse effect. Fifteen children completed treatment. All adverse effects were transient.