Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019
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DOI：
10.1002/ana.26041
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发表时间：
2021-02-24
影响因子：
11.2
通讯作者：
Silva, Marcus Tulius T.
中科院分区：
文献类型：
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作者：
Espindola, Otavio M.;Gomes, Yago C. P.;Silva, Marcus Tulius T.
2019冠状病毒病（COVID-19）患者可能会出现不同的神经系统表现。这项研究表明，炎性神经系统疾病与脑脊液中白细胞介素（IL）-2，IL-4，IL-6，IL-10，IL-12，趋化因子（C-X-C基序）配体8（CXCL 8）和CXCL 10水平升高相关。相反，脑病与高血清IL-6、CXCL 8和活性肿瘤生长因子β 1水平相关。COVID-19中的中枢神经系统炎症综合征可以早期出现，作为一种无显著全身受累的副作用过程，或没有严重急性呼吸系统综合征冠状病毒2型神经侵入的直接证据。同时，脑病主要受外周事件的影响，包括炎性细胞因子。ANN NEUROL 2021
Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor beta 1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines. ANN NEUROL 2021