On the origin and transmission of force in actomyosin subfragment 1.
On the origin and transmission of force in actomyosin subfragment 1.
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关于肌动球蛋白亚片段1中力的起源和传递。
DOI：
10.1073/pnas.86.7.2204
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发表时间：
1989
影响因子：
11.1
通讯作者：
Morales,MF
中科院分区：
文献类型：
--
作者：
Botts,J;Thomason,JF;Morales,MF
一个接近地图显示的三维排列的12个化学定义的点在肌动球蛋白亚片段1的开发和大致与已发表的电子显微镜重建他人。在初级多肽链折叠中的几个额外的点和拓扑关系被同化到这个模型中。某些交联和距离变化的观察结果被解释为核苷酸结合位点和肌动蛋白结合位点之间力/位移传递的指标-即，作为能量在这个系统中如何转换的指示。
A proximity map showing the three-dimensional arrangement of 12 chemically defined points in actomyosin subfragment 1 is developed and roughly correlated with published electron microscope reconstruction of others. Several additional points and topological relationships in the primary polypeptide chain folding are assimilated into this model. Certain crosslinkings and distance change observations are interpreted as indicators of transmission of force/displacement between the nucleotide-binding and an actin-binding site--i.e., as indications of how energy is transduced in this system.