Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents
Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents
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DOI：
10.1016/j.metabol.2007.01.011
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发表时间：
2007-06-01
影响因子：
9.8
通讯作者：
Urban, Miroslawa
中科院分区：
文献类型：
--
作者：
Glowinska-Olszewska, Barbara;Urban, Miroslawa
基质金属蛋白酶（MMPs）与动脉粥样硬化过程和成人高血压、高脂血症、糖尿病等疾病的危险因素有关。到目前为止，还没有对肥胖儿童和青少年的MMPs及其组织抑制剂（TIMPs）的循环水平进行评估，肥胖是心血管疾病的已知危险因素。对45名年龄为15 ± 1.8岁的肥胖儿童和青少年的血浆MMP-9和TIMPI水平进行了免疫酶法测定。对照组由28名健康儿童组成，年龄为14.5 ± 2.5岁。肥胖儿童的MMP-9和TIMP-1浓度高于对照组（MMP-9：553.5 +/- 311 vs 400.4 +/- 204 ng/mL; P = 0.02; TIMP-1：161.2 +/- 32 vs 143.1 +/- 20.1 ng/mL; P = 0.03）。我们发现，与肥胖的正常血压患者相比，肥胖的高血压儿童的MMP-9水平显著更高（分别为635 +/- 308 vs 450 289 ng/mL; P = 0.04）。MMP-9与体重指数（BMI）（r = 0.33，P= 0.005）和空腹胰岛素（r = 0.3，P = 0.013）相关; TIMP-1与BMI相关（r = 0.35，P = 0.006）。在肥胖高血压儿童组中，MMP-9与BMI（r = 0.41，P = 0.001）、收缩压（r =-0.41，P = 0.002）、空腹胰岛素（r = 0.37，P = 0.006）和胰岛素抵抗的稳态模型评估指数（r = 0.27，P = 0.03）相关。TIMP-1与BMI（r = 0.33，P = 0.025）、收缩压（r = 0.38，P = 0.008）和舒张压（r = 0.47，P = 0.001）相关。在回归模型中，发现MMP-9依赖于空腹胰岛素（R-2 = 0. 16，P =.04），而TIMP-1对BMI影响（R-2 = 0.14，P =.04）。在肥胖高血压组中，TIMP-1 2依赖于舒张压（R-2 = 0.18，P -0.04）。肥胖儿童和青少年血浆MMP-9和TIMP-1浓度升高。高血压的共存可能会加剧这些患者细胞外基质周转的改变。可能假设MMP和TIMP浓度升高可能与肥胖，特别是肥胖高血压儿童和青少年的心血管风险增加有关。(c)2007爱思唯尔公司All rights reserved.
Matrix metal loprotemases (MMPs) have been implicated in the atherosclerotic process and risk factors for the disease such as hypertension, hyperlipidemia, or diabetes mellitus in adults. So far, circulating levels of MMPs and their tissue inhibitors (TIMPs) have not been assessed in children and adolescents with obesity, a known risk factor for cardiovascular disease. Plasma levels of MMP-9 and TIMPI were measured immunoenzymaticatly in 45 obese children and adolescents, aged 15 +/- 1.8 years. The control group consisted of 28 healthy children, aged 14.5 +/- 2.5 years. MMP-9 and TIMP-1 concentrations were higher in obese children than in the control group (MMP-9: 553.5 +/- 311 vs 400.4 +/- 204 ng/mL, respectively; P =.02; TIMP-1: 161.2 +/- 32 vs 143.1 +/- 20.1 ng/mL, respectively; P =.03). We found significantly higher levels of MMP-9 in obese children with coexisting hypertension than in obese normotensive patients (635 +/- 308 vs 450 289 ng/mL, respectively; P =.04). MMP-9 correlated with body mass index (BMI) (r = 0.33, P= .005) and fasting insulin (r = 0.3 P = .013); TIMP-1 correlated with BMI (r = 0.35, P =.006). In the group of obese hypertensive children m = 25) MMP-9 correlated with BMI (r = 0.41, P =.001), systolic blood pressure (r = - 0.41, P -.002), fasting insulin (r = 0.37, P = .006), and homeostasis model assessment index of insulin resistance (r = 0.27, P =.03). TIMP-1 correlated with BMI (r = 0.33, P = .025) and systolic (r = 0.38 P =.008) and diastolic (r = 0.47, P =.001) blood pressure. In the regression models, MMP-9 was found to be dependent on fasting insulin (R-2 = 0. 16, P =.04), and TIMP-1 on BMI (R-2 = 0.14, P =.04). In the obese hypertensive group, TIMP-1 2 was dependent on diastolic blood pressure (R-2 = 0.18, P -.04). Obese children and adolescents have elevated plasma concentrations of MMP-9 and TIMP-1. Coexistence of hypertension may exacerbate alterations of extracellular matrix turnover in these patients. It might be hypothesized that elevated MMP and TIMP concentrations may be related to increased cardiovascular risk in obese and particularly in obese hypertensive children and adolescents. (c) 2007 Elsevier Inc. All rights reserved.