Spatiotemporal behavior of T cells in vaccination.
Spatiotemporal behavior of T cells in vaccination.
复制标题
疫苗接种中 T 细胞的时空行为。
DOI：
10.1016/j.biocel.2022.106224
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Chiodetti AL
中科院分区：
文献类型：
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作者：
Chiodetti AL
疫苗是控制和消除传染病的最具成本效益的资源。尽管在该领域进行了数十年的研究，但有几种病原体未能达到传统疫苗的效果，主要是因为它们未能诱导强烈的T细胞反应。需要新的疫苗技术来克服这个问题。最近成像技术的进步使得研究T细胞在其周围的细胞壁龛内的动力学成为可能。这些信息对于阐明靶向疫苗的主要细胞机制以优化疫苗效率是非常有价值的。在这篇综述中，我们总结了在疫苗接种和免疫的背景下T细胞行为的最新关键发现。
Vaccines are the most cost-effective resource to contain and eliminate infectious diseases. Despite decades of research in the field, several pathogens have eluded the effect of conventional vaccines mostly due their failure in inducing strong T cell responses. There is a need for new vaccine technologies that can surpass this problem. Recent advances in imaging techniques have allowed the study of T cell dynamics within their surrounding cellular niches. This information is invaluable to elucidate the main cellular mechanisms to target in order to optimize vaccine efficiency. In this review, we summarize the most recent key discoveries in T cell behavior in the context of vaccination and immunization.