Neuropsychological assessment in mixed connective tissue disease: comparison with systemic lupus erythematosus
Neuropsychological assessment in mixed connective tissue disease: comparison with systemic lupus erythematosus
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DOI：
10.1177/0961203312441511
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发表时间：
2012-08-01
期刊：
影响因子：
2.6
通讯作者：
Siebert, J.
中科院分区：
文献类型：
--
作者：
Nowicka-Sauer, K.;Czuszynska, Z.;Siebert, J.
目的：本研究的目的是评估混合性结缔组织病（MCTD）患者的认知功能（CF），并比较MCTD患者与有和无神经精神症状的系统性红斑狼疮患者（分别为NP-SLE和非NP-SLE）的CF。研究方法：对141例患者进行神经心理学检查：MCTD 30例（女性24例，男性6例），平均年龄：48.07岁;非NP-SLE 37例（女性36例，男性1例），平均年龄：40.76岁; NP-SLE 74例（女性68例，男性6例），平均年龄：41.97岁。采用神经心理测验和结构化访谈。情绪状态采用医院焦虑抑郁量表和临床回顾进行评估。结果：我们观察到6例MCTD患者（20%）的认知功能障碍，其中1例（3%）的损害严重。与NP-SLE患者相比，MCTD患者在11项测试中的7项中获得了显着更高的结果。MCTD和非NP-SLE患者无显著差异。这种差异与发病前的智商、教育程度、病程和类固醇治疗无关。结论：在大多数MCTD患者中，CF没有受损，严重受损是罕见的。NP-SLE患者的认知功能障碍最严重。在结缔组织疾病中观察到的认知缺陷可能与神经系统受累有关。Lupus（2012）21，927-933.
Objective: The aims of the study were to assess cognitive functions (CF) in patients with mixed connective tissue disease (MCTD) and to compare MCTD patients with systemic lupus erythematosus patients with and without neuropsychiatric manifestations (NP-SLE and non-NP-SLE, respectively) in terms of CF. Methods: Neuropsychological examination was performed in 141 patients: 30 with MCTD (24 women, 6 men), mean age: 48.07 years, 37 with non-NP-SLE (36 women, 1 man), mean age: 40.76 years and 74 with NP-SLE (68 women, 6 men), mean age: 41.97 years. Neuropsychological tests and structured interview were used. Emotional state was assessed by Hospital Anxiety and Depression Scale and clinical review. Results: We observed cognitive impairment in six MCTD patients (20%); in one (3%) the impairment was severe. MCTD patients achieved significantly higher results in seven out of 11 tests compared with patients with NP-SLE. MCTD and non-NP-SLE patients did not differ significantly. The differences were irrespective of premorbid IQ, education, disease duration and steroid treatment. Conclusions: In the majority of MCTD patients, CF were not impaired and severe impairment was unusual. Cognitive functioning was most disturbed in NP-SLE. The cognitive deficits observed in connective tissue diseases can be connected with nervous system involvement. Lupus (2012) 21, 927-933.