Neuro-immune communication in C. elegans defense against pathogen infection.
Neuro-immune communication in C. elegans defense against pathogen infection.
复制标题
秀丽隐杆线虫防御病原体感染中的神经免疫通信。
DOI：
10.1016/j.crimmu.2021.04.002
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发表时间：
2021
影响因子：
--
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Wibisono P;Sun J
先天免疫系统是一个复杂的集合物理屏障和生理防御反应的内部和外部环境的攻击。最近在模式生物秀丽隐杆线虫中的研究强调了神经系统如何与先天免疫系统相互作用以产生协调的保护性反应。事实上，对神经免疫相互作用途径的研究已经为神经免疫通讯在调节对病原体攻击的免疫和行为反应中的作用提供了机制性的见解。神经系统释放各种神经递质、肽和激素，调节先天免疫反应，而先天免疫系统也将信息传递给神经系统，以影响学习和行为反应。虽然这些相互作用仍需要进一步研究，但我们迄今为止所获得的知识已经提高了我们对独立生物系统如何为有机体的生存和福祉共同行动的理解。在这里，我们回顾了最近的研究神经免疫通讯相关的生存和防御线虫对病原体。神经免疫通讯对于产生针对病原体感染的协调防御以提高宿主存活率至关重要。神经免疫通讯调节对病原体攻击的免疫和行为反应。秀丽隐杆线虫是研究神经免疫通讯的极好模型系统。
The innate immune system is a complex collection of physical barriers and physiological defense responses to internal and external environmental assaults. Recent studies in the model organism Caenorhabditis elegans have highlighted how the nervous system interacts with the innate immune system to generate coordinated protective responses. Indeed, studies on neuro-immune interaction pathways have provided mechanistic insights into the roles of neuro-immune communication in modulating both immune and behavioral responses to pathogen attacks. The nervous system releases a variety of neurotransmitters, peptides, and hormones that regulate the innate immune response, while the innate immune system also relays information to the nervous system to affect learning and behavioral responses. Although these interactions still need further investigation, the knowledge that we have gained thus far has improved our understanding of how separate biological systems can act collectively for the survival and well-being of an organism. Here, we review recent studies on neuro-immune communication related to the survival and defense of C. elegans against pathogens. Neuro-immune communication is essential for generating coordinated defense against pathogen infection to improve host survival. Neuro-immune communication modulates both immune and behavioral responses to pathogen attacks. C.elegans is an excellent model system for studying neuro-immune communication.