FUNCTIONAL-ROLE OF GABA IN CAT PRIMARY SOMATOSENSORY CORTEX - SHAPING RECEPTIVE-FIELDS OF CORTICAL-NEURONS
FUNCTIONAL-ROLE OF GABA IN CAT PRIMARY SOMATOSENSORY CORTEX - SHAPING RECEPTIVE-FIELDS OF CORTICAL-NEURONS
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DOI：
10.1152/jn.1984.52.6.1066
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
HICKS, TP
中科院分区：
文献类型：
--
作者：
DYKES, RW;LANDRY, P;HICKS, TP
使用含有碳纤维的多管微量移液器获得了 209 个神经元的细胞外记录。这些细胞是在巴比妥麻醉的猫的初级体感皮层中分离出来的，并根据它们对自然刺激的反应性质、周围多单位对相同刺激的反应性质、对丘脑刺激的反应以及它们在皮层中的深度进行分类。为了研究控制体感神经元兴奋性的因素，在离子导入 GABA、谷氨酸和荷包牡丹碱 (BMI) 的情况下检查它们的感受野。这些实验揭示了控制感受野大小和神经元反应的一些其他特性的皮质内机制。皮质神经元的感受野是一种动态现象，能够被影响 GABA 介导的抑制强度的因素改变。讨论了该机制的几个假设角色。
Extracellular recordings of 209 neurons were obtained with carbon fiber-containing multibarrel micropipettes. The cells were isolated in the primary somatosensory cortex of cats anesthetized with barbiturate and classified according to the nature of their response to natural stimuli, the nature of the surrounding multiunit responses to the same stimuli, the response to thalamic stimulation, and their depth in the cortex. To study factors controlling the excitability of somatosensory neurons, their receptive fields were examined in the presence of iontophoretically administered GABA, glutamate and bicuculline methiodide (BMI). These experiments revealed an intracortical mechanism that controls receptive-field size and some other properties of the neuronal response. The receptive field of a cortical neuron is a dynamic phenomenon capable of being altered by factors that influence the strength of GABA-mediated inhibition. Several postulated roles for this mechanism are discussed.