SEROCONVERSION FROM HEPATITIS-B-E ANTIGEN TO ANTIBODY IN CHRONIC TYPE-B HEPATITIS
SEROCONVERSION FROM HEPATITIS-B-E ANTIGEN TO ANTIBODY IN CHRONIC TYPE-B HEPATITIS
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DOI：
10.7326/0003-4819-94-6-744
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发表时间：
1981-01-01
影响因子：
39.2
通讯作者：
BALES, ZB
中科院分区：
文献类型：
--
作者：
HOOFNAGLE, JH;DUSHEIKO, GM;BALES, ZB
对25例经肝活检证实的慢性乙型病毒性肝炎患者进行了1~6年的随访，并进行了转氨酶、乙肝表面抗原(HBs)、e抗原(HBeAg)、抗体(抗-HBe)和乙肝病毒DNA聚合酶(HBVDNA聚合酶)的检测。最初，所有患者的HBs Ag和HBeAg均为阳性，血清转氨酶均升高。随访中，仅1例HBs Ag反应消失。在13例升高的患者中，转氨酶水平自然降至正常并保持正常。这13人也有从HBeAg到抗HBe的血清转换，并且都是血清DNA聚合酶阴性。大多数患者的乙肝表面抗原滴度都有所下降。这种血清转换与转氨酶水平下降同时发生，或在下降前几个月发生。保持HBeAg阳性的12名患者的转氨酶水平持续升高。所有这些最初DNA聚合酶阳性的10名患者都保持阳性。许多慢性乙型肝炎患者的临床和生化证据表明，活动性疾病最终会自然缓解，通常是HBeAg和DNA聚合酶消失的先兆或伴随。
Twenty-five patients with chronic type B hepatitis documented by liver biopsy were followed for 1-6 yr with serial measurements of aminotransferase levels, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and antibody (anti-HBe) and hepatitis B virus DNA polymerase. Initially, all were positive for HBsAg and HBeAg and had elevations in serum aminotransferases. In follow-up, only 1 lost HBsAg reactivity. In 13 elevated aminotransferase levels spontaneously fell to normal and remained normal. These 13 also had a seroconversion from HBeAg to anti-HBe and all became negative for serum DNA polymerase. Most had a fall in HBsAg titer. This seroconversion occurred concurrently with or several months before the fall in aminotransferase levels. The 12 persons who remained HBeAg positive continued to have elevated aminotransferase levels. All 10 of these patients who were initially positive for DNA polymerase remained positive. Many patients with chronic type B hepatitis apparently eventually have a spontaneous remission in clinical and biochemical evidence of active disease, usually heralded or accompanied by the disappearance of HBeAg and DNA polymerase.