The role of ventral frontostriatal circuitry in reward-based learning in humans
The role of ventral frontostriatal circuitry in reward-based learning in humans
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DOI：
10.1523/jneurosci.2431-05.2005
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发表时间：
2005-09-21
影响因子：
5.3
通讯作者：
Casey, BJ
中科院分区：
文献类型：
--
作者：
Galvan, A;Hare, TA;Casey, BJ
这项研究考察了奖励学习对行为和神经活动的影响。使用事件相关功能磁共振成像范式，我们发现伏隔核、丘脑和眼眶额叶皮质对奖赏大小都很敏感，其中伏隔核显示出对奖赏价值的最大区分。对于预测最大奖励的线索，平均反应时间明显更快，而对于预测最小奖励的线索，平均反应时间则更慢。在实验过程中，伏隔核活动的峰值从对奖赏的期待(反应后立即)转移到了预测奖赏的线索上，这与行为变化是平行的。在整个实验过程中，眼眶前额区和丘脑区域在对奖励的预期中达到了顶峰。我们的发现表明，基底节丘脑皮质回路中的区域在调节行为以最大化奖励方面具有离散的功能。
This study examined changes in behavior and neural activity with reward learning. Using an event-related functional magnetic resonance imaging paradigm, we show that the nucleus accumbens, thalamus, and orbital frontal cortex are each sensitive to reward magnitude, with the accumbens showing the greatest discrimination between reward values. Mean reaction times were significantly faster to cues predicting the greatest reward and slower to cues predicting the smallest reward. This behavioral change over the course of the experiment was paralleled by a shift in peak in accumbens activity from anticipation of the reward ( immediately after the response), to the cue predicting the reward. The orbitofrontal and thalamic regions peaked in anticipation of the reward throughout the experiment. Our findings suggest discrete functions of regions within basal ganglia thalamocortical circuitry in adjusting behavior to maximize reward.