Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis
Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis
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DOI：
10.1016/j.clnu.2021.06.009
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发表时间：
2021-07-01
影响因子：
6.3
通讯作者：
Ma, Bin
中科院分区：
文献类型：
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作者：
Gao, Qianqian;Mei, Fan;Ma, Bin
背景与目的：肌萎缩性肥胖症（Sarkroic obesity，SO）是指肌肉减少症和肥胖症并存的疾病。它可能导致身体残疾、发病甚至死亡。本系统性综述和荟萃分析旨在估计老年人SO的全球患病率。方法：我们在PubMed、Embase和Web of Science中检索了从成立到2020年12月报告SO患病率的研究。两名研究人员独立筛选文献，评估研究质量并提取数据。使用随机效应模型汇总SO患病率的估计值。进行了亚组分析、敏感性分析和荟萃回归分析。使用漏斗图和Egger检验评估发表偏倚。所有统计分析均使用Stata 15.0软件进行。结果：本综述纳入了50项研究，我们发现全球老年人SO患病率为11%。亚组分析显示，在仅使用肌肉质量诊断标准（15%）诊断肌肉减少症的研究中，使用双能X射线吸收测定法（15%）评估肌肉质量的研究中，SO的患病率较高，而那些专注于年龄> 75岁（23%），住院（16%），南美人（21%）和北美人（19%）。使用体脂百分比（10%）、体重指数（13%）、腰围（16%）诊断肥胖的研究以及女性（14%）、男性（10%）患者中SO的患病率没有显着差异。敏感性分析表明，这些研究均不影响总体汇总结果。荟萃回归分析发现，出版年份，地理区域，研究设置，和肌肉减少症的诊断标准的异质性的来源。结论：这项荟萃分析表明，SO影响全球超过十分之一的老年人。因此，应重视对老年人SO的筛查和早期诊断，并选择适当的干预措施，以减少其发生和各种不良后果。0 2021爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Sarcopenic obesity (SO), which refers to the coexistence of sarcopenia and obesity. It can lead to physical disability, morbidity, and even mortality. This systematic review and meta-analysis aimed to estimate the global prevalence of SO in older adults. Methods: We searched PubMed, Embase, and Web of Science for studies reporting the prevalence of SO from inception to December 2020. Two researchers independently screened the literature, evaluated study quality, and extracted data. A random-effects model was used to pool the estimates for the prevalence of SO. Subgroup analysis, sensitivity analysis, and meta-regression analysis were conducted. Publication bias was assessed using a funnel plot and the Egger test. All statistical analyses were performed using Stata 15.0 software. Results: This review included 50 studies, we found that the global prevalence of SO in older adults was 11%. Subgroup analyses showed that the prevalence of SO was higher among studies using diagnostic criteria of muscle mass alone (15%) to diagnose sarcopenia, using dual-energy X-ray absorptiometry (15%) to assess muscle mass, and those focused on age > 75 years old (23%), hospitalized (16%), South Americans (21%) and North Americans (19%). There were no significant differences in the prevalence of SO among studies using body fat percentage (10%), body mass index (13%), waist circumference (16%) to diagnose obesity and in female (14%), male (10%) patients. Sensitivity analysis showed that none of the studies affected the overall pooled results. Meta-regression analysis found that publication year, geographical region, study setting, and the diagnostic criteria of sarcopenia were sources of heterogeneity. Conclusion: This meta-analysis indicated SO affects more than one in ten older adults globally. Therefore, we should attach importance to the screening and early diagnosis of SO in older adults, then selecting appropriate interventions to reduce the occurrence of it and various adverse outcomes in this demographic. 0 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.